2. GPCR/G Protein
  3. LPL Receptor
  4. Ex26

Ex26  (Synonyms: S1P1-IN-Ex26)

目录号: HY-117213
产品使用指南

摩尔计算器

Ex26 (S1P1-IN-Ex26) 是一种强效和选择性的 sphingosine 1-phosphate receptor 1 (S1P1) 拮抗剂 (IC50=0.93 nM)，对 S1P1 的选择性大于其他 Sphingosine 1-phosphate receptor 约 3,000 倍。Ex26 可用于实验性自身免疫性脑脊髓炎的研究。

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Ex26 Chemical Structure

Ex26 Chemical Structure

CAS No. : 1233332-37-0

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规格 价格 是否有货 数量
5 mg ￥3093
3 - 4 周
10 mg ￥4946
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

Ex26 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

查看所有亚型
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].

IC50 & Target

IC50: 0.93 nM (S1P1)[1]
体外研究
(In Vitro)

Ex26 (0-10 μM; 1 h) treatment shows excellent selectivity for S1P1 over other Sphingosine 1-phosphate receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ex26 相关抗体:

Cell Viability Assay[1]

Cell Line: U2OS cells, and Chinese hamster ovary cells
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Confirmed a potent and selective antagonist of S1P1 (IC50=0.93 nM).
体内研究
(In Vivo)

Ex26 (i.p.; 3 mg/kg; once daily; 3 d) treatment disrupts S1P1 signaling inhibiting the lymphocyte and thymocyte egress[1].
Ex26 (i.p.; 30 mg/kg; once daily; 15 d) treatment alleviates experimental autoimmune encephalomyelitis by S1P1 antagonism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57Bl/6J mice[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; 3 mg/kg; once daily; 3 days
Result: Induced lymphocyte sequestration at low doses, possessing an ED50 of 0.06 mg/kg after 2 hours treatment. Led to significant retention of T and B cells within the lymph nodes and significant decreases in T and B cells within the spleen.
Animal Model: Eight-week-old male C57Bl/6J mice induced with experimental autoimmune encephalomyelitis[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; 15 days
Result: Inhibited both lymphocyte infiltration and destruction of the white matter in the spinal cord of mice euthanized at the end of the experiment.
分子量

494.98

Formula

C28H28ClFN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ex26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ex261233332-37-0S1P1-IN-Ex26Ex 26Ex-26LPL ReceptorLysophospholipid Receptorexperimental autoimmune encephalomyelitisEAEU2OSChinese hamster ovary cellsInhibitorinhibitorinhibit

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