2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species MMP Caspase
  4. Ganoderic acid Mk

Ganoderic acid Mk  (Synonyms: GA-Mk)

目录号: HY-N11643
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摩尔计算器

Ganoderic acid Mk (GA-Mk) 是一种三萜酸，可从灵芝菌丝中分离得到。Ganoderic acid Mk 具有有效的抗增殖作用，可通过线粒体介导的途径诱导 HeLa 细胞凋亡(apoptosis)。Ganoderic acid Mk 可用于宫颈癌研究。

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Ganoderic acid Mk Chemical Structure

Ganoderic acid Mk Chemical Structure

CAS No. : 110024-14-1

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Ganoderic acid Mk 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2].

IC50 & Target

Caspase-3

 

Caspase-9

 

体外研究
(In Vitro)

Ganoderic acid Mk (0-100 μM, 24 h) 对人类癌细胞表现出比人类正常细胞系更强的细胞毒性[1]。
Ganoderic acid Mk (0-40 μM, 12-48 h) 对HeLa细胞增殖具有剂量依赖性抑制作用[1]。
Ganoderic acid Mk (0-40 μM, 24 h) 诱导HeLa细胞凋亡[1]。
Ganoderic acid Mk (0-40 μM, 24 h) 诱导 ROS 爆发，MMP 减少和 caspase-3, -9 活性增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid Mk 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Human normal cell lines (MCF-10A and HF) and cancer cell lines (HO-8910PM, SW1990, 95-D and HeLa)
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Exhibited stronger cytotoxicity to human cancer cells (IC50 values were ranged within 29.8-44.2 µM) than human normal cell lines (IC50 values to MCF-10A and HF were 84.5 µM and 78.4 µM, respectively).

Cell Viability Assay[1]

Cell Line: HeLa cells
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 12, 24, 48 h
Result: Showed cytotoxicity on HeLa cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 0, 10, 20, 40 μM
Incubation Time: 24 h
Result: Increased the rate of early and late apoptotic cells in a dose-dependent manner in HeLa cells. GA-Mk could induce HeLa cells apoptosis in parallel with the accumulation of ROS, the loss of MMP and the activation of activities of caspases.
分子量

570.76

Formula

C34H50O7
CAS 号
结构分类
初始来源

glossy ganoderma
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ganoderic acid Mk 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ganoderic acid Mk110024-14-1GA-MkApoptosisReactive Oxygen SpeciesMMPCaspaseMatrix metalloproteinasesanti-proliferationHeLa cellsGanoderma lucidumMitochondriacervical cancerInhibitorinhibitorinhibit

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