2. Gene
  3. TSPAN2 - tetraspanin 2 Gene

TSPAN2 - tetraspanin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 直系同源

中文名称：四跨膜蛋白 2

种属: Homo sapiens

同用名: NET3; TSN2; TSPAN-2

基因 ID: 10100 | 基因类型: protein coding

关于 TSPAN2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:115,048,011-115,089,503 (from NCBI)

This gene has 4 transcripts (splice variants), 269 orthologues and 32 paralogues. Broad expression in endometrium (RPKM 16.8), urinary bladder (RPKM 10.7) and 19 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

TSPAN2 基因产物(3)

mRNA Protein Name
NM_001308315.2 NP_001295244.1 tetraspanin-2 isoform 2
NM_001308316.2 NP_001295245.1 tetraspanin-2 isoform 3
NM_005725.6 NP_005716.2 tetraspanin-2 isoform 1

TSPAN2 蛋白结构

Tetraspannin

Tetraspannin: Tetraspanin family (10 - 214)

  • 0
  • 100
  • 200
  • 221 a.a.
蛋白主名 其他名称

tetraspanin-2

new EST tetraspan 3

关联疾病

疾病名称 别名
Migraine, Familial Hemiplegic, 2

FHM2

Mhp2

Migraine, Familial Basilar

Familial Hemiplegic Migraine 2

Familial Hemiplegic Migraine-2

Familiar Basilar Migraine

Migraine, Hemiplegic, Familial, Type 2
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Clonorchiasis

Oriental Liver Fluke Disease

Clonorchis Liver Infection

Clonorchiosis

Chinese Liver Fluke Disease

Hepatic Distomiasis Due To Clonorchis Sinensis

Infection Due To Clonorchis Sinensis

Hepatic Distomiasis

Hepatic Distomatosis

Chinese Liver Fluke Disorder

Oriental Liver Fluke Disorder

Clonorchis Infestation

Chinese Liver Fluke Infestation

Liver Fluke Disease Due To Clonorchis Sinensis

Oriental Liver Fluke Infestation
Migraine, Familial Hemiplegic, 3

FHM3

Familial Hemiplegic Migraine 3

Mhp3

Migraine, Hemiplegic, Familial, Type 3
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TSPAN2 RGD RGD:620982
Bos taurus TSPAN2 VGNC VGNC:36435
Macaca mulatta TSPAN2 VGNC VGNC:79264
Felis catus TSPAN2 VGNC VGNC:66630
Mus musculus TSPAN2 MGD MGI:1917997
Canis familiaris TSPAN2 VGNC VGNC:47918
Others TSPAN2 NCBI