1. Gene
  2. RNF19B - ring finger protein 19B Gene

RNF19B - ring finger protein 19B Gene

中文名称:无名指蛋白 19B

种属: Homo sapiens

同用名: NKLAM; IBRDC3

基因 ID: 127544 | 基因类型: protein coding

关于 RNF19B

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,929,036-32,964,809 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 9 paralogues. Broad expression in testis (RPKM 31.7), bone marrow (RPKM 15.6) and 23 other tissues.

功能概要

该基因编码包含两个 RING 型和一个 IBR 型锌指基序的多通道膜蛋白。编码的蛋白质是一种 E3 泛素蛋白连接酶,在自然杀伤 (NK) 细胞的细胞毒性作用中发挥作用。可变剪接导致多个转录本变体。在可能的假常染色体区域的 X 和 Y 染色体上存在该基因的假基因。[RefSeq 提供,2014 年 7 月]

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

RNF19B 基因产物(3)

mRNA Protein Name
NM_001127361.3 NP_001120833.1 E3 ubiquitin-protein ligase RNF19B isoform b
NM_001300826.2 NP_001287755.1 E3 ubiquitin-protein ligase RNF19B isoform c
NM_153341.4 NP_699172.2 E3 ubiquitin-protein ligase RNF19B isoform a

RNF19B 蛋白结构

IBR

IBR: IBR domain, a half RING-finger domain (187 - 251)

IBR

IBR: IBR domain, a half RING-finger domain (282 - 326)

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  • 732 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF19B

IBR domain-containing protein 3

直系同源

种属 基因名 来源 基因 ID
Felis catus RNF19B VGNC VGNC:80344
Mus musculus RNF19B MGD MGI:1922484
Bos taurus RNF19B VGNC VGNC:34045
Rattus norvegicus RNF19B RGD RGD:1305470
Macaca mulatta RNF19B VGNC VGNC:106488
Canis familiaris RNF19B VGNC VGNC:45651