1. Gene
  2. CDK8 - cyclin dependent kinase 8 Gene

CDK8 - cyclin dependent kinase 8 Gene

中文名称:细胞周期蛋白依赖性激酶 8

种属: Homo sapiens

同用名: K35; IDDHBA

基因 ID: 1024 | 基因类型: protein coding

关于 CDK8

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,254,129-26,405,238 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 6.1), duodenum (RPKM 3.9) and 25 other tissues.

功能概要

该基因编码细胞周期蛋白依赖性蛋白激酶 (CDK) 家族的成员。已知 CDK 家族成员是细胞周期进程的重要调节因子。这种激酶及其调节亚基细胞周期蛋白 C 是 Mediator 转录调节复合物的组分,通过 RNA 聚合酶 II 最大亚基的羧基末端结构域的磷酸化参与转录激活和抑制。该激酶通过靶向一般转录起始因子 IIH 的细胞周期蛋白依赖性激酶 7 亚基来调节转录,从而提供介体复合物和基础转录机制之间的联系。已鉴定出该基因的多个假基因。可变剪接导致多个转录本变体。[RefSeq 提供,2016 年 10 月]

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

CDK8 基因产物(5)

mRNA Protein Name
NM_001318368.2 NP_001305297.1 cyclin-dependent kinase 8 isoform 2
NM_001346501.2 NP_001333430.1 cyclin-dependent kinase 8 isoform 3
XM_047430033.1 XP_047285989.1 cyclin-dependent kinase 8 isoform X1
XM_011534865.3 XP_011533167.1 cyclin-dependent kinase 8 isoform X2
NM_001260.3 NP_001251.1 cyclin-dependent kinase 8 isoform 1

CDK8 蛋白结构

Pkinase

Pkinase: Protein kinase domain (26 - 335)

  • 0
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  • 400
  • 464 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 8

CDK8 protein kinase

cell division protein kinase 8

mediator complex subunit CDK8

mediator of RNA polymerase II transcription subunit CDK8

protein kinase K35

关联疾病

疾病名称 别名
Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Mental Retardation-18

Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax

Ebstein Anomaly

Ebstein'S Anomaly

Ebstein'S Anomaly Of Common Atrioventricular Valve

Ebstein'S Anomaly Of Right Atrioventricular Valve

Ebstein'S Anomaly Of Tricuspid Valve

Ebstein'S Malformation

Ebstein Malformation Of The Tricuspid Valve

Ebstein Anomaly Of The Tricuspid Valve

Ebstein Disease

Accessory Tricuspid Valve Tissue

Congenital Ebstein Deformity Of Tricuspid Valve

Ebstein Syndrome

Ebstein Cardiopathy

Ebstein Anomaly Of Tricuspid Valve

Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Ohdo Syndrome

Young Simpson Syndrome

Ohdo Blepharophimosis Syndrome

Blepharophimosis Syndrome Ohdo Type

Blepharophimosis Intellectual Disability Syndromes

Bmrs

Blepharophimosis-Intellectual Disability Syndrome

Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth

Blepharophimosis Mental Retardation Syndromes

Sbbys Syndrome

Say Barber Biesecker Young-Simpson Syndrome

Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type

Bmrs, Ohdo Type

Blepharophimosis Syndrome, Ohdo Type

Ohdo-Madokoro-Sonoda Syndrome

Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type

Blepharophimosis - Intellectual Disability Syndrome

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Uterine Benign Neoplasm
Developmental And Epileptic Encephalopathy 87

DEE87

Epileptic Encephalopathy, Early Infantile, 87

Eiee87

Developmental And Epileptic Encephalopathy, 87

Early Infantile Epileptic Encephalopathy 87

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities

IDDHBA

Heart, Malformation Of
Hydrocephalus, Congenital, 1

Hydrocephaly

Ventriculomegaly

Hydrocephalus, Nonsyndromic, Autosomal Recessive 1

HYC1

Congenital Non-Communicating Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly

Congenital Obstructive Hydrocephalus

Hydrocephalus, Non-Syndromic, Autosomal Recessive 1

Hydrocephalus

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Hernia, Congenital Diaphragmatic 1

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CDK8 MGD MGI:1196224
Felis catus CDK8 VGNC VGNC:60706
Rattus norvegicus CDK8 RGD RGD:1560888
Macaca mulatta CDK8 VGNC VGNC:70984
Canis familiaris CDK8 VGNC VGNC:39061
Bos taurus CDK8 VGNC VGNC:27135
Others CDK8 NCBI