2. Gene
  3. SPIN1 - spindlin 1 Gene

SPIN1 - spindlin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：主轴 1

种属: Homo sapiens

同用名: SPIN; TDRD24

基因 ID: 10927 | 基因类型: protein coding

关于 SPIN1

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,388,444-88,478,694 (from NCBI)

This gene has 6 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 40.9), brain (RPKM 36.4) and 25 other tissues.

功能概要

启用甲基化组蛋白结合活性。参与 Wnt 信号通路的正向调控；转录的正调控，DNA 模板化；和 rRNA 转录。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables methylated histone binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of transcription, DNA-templated; and rRNA transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SPIN1 基因产物(1)

mRNA Protein Name
NM_006717.3 NP_006708.2 spindlin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
21029866 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24589551 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
29061846 GOA
involved in positive regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
24589551 GOA
involved in rRNA transcription IDA
IDA: 通过直接分析推断
21960006 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
21960006 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29061846 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPIN1 蛋白结构

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (54 - 102)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (133 - 182)

Spin-Ssty

Spin-Ssty: Spin/Ssty Family (214 - 259)

  • 0
  • 100
  • 200
  • 262 a.a.
蛋白主名 其他名称

spindlin-1

ovarian cancer-related protein

SPIN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SPIN1 Q9Y657 HSPB1 Homo sapiens P04792
Anti Bait CoIP
25277244
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acquired Color Blindness

Acquired Color Vision Deficiencies

Acquired Color Vision Deficiency

Acquired Colour Blindness

Acquired Colour Vision Deficiencies

Acquired Colour Vision Deficiency
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125837A MS31 trihydrochloride Inhibitor 98.0% 否
HY-RS13675 SPIN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-125837 MS31 Inhibitor / 否
HY-163460 MS8535 Inhibitor / 否
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-161068 hACE2/SP-IN-1 Inhibitor / 否
HY-RS22825 Spin1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29340 Spin1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SPIN1 VGNC VGNC:77859
Mus musculus SPIN1 MGD MGI:109242
Felis catus SPIN1 VGNC VGNC:102985
Rattus norvegicus SPIN1 RGD RGD:1306210
Bos taurus SPIN1 VGNC VGNC:35217
Canis familiaris SPIN1 VGNC VGNC:46742
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