Dhfr - dihydrofolate reductase Gene

中文名称：二氢叶酸还原酶

种属: Mus musculus

同用名: 8430436I03Rik

关于 Dhfr

功能概要

该基因编码的蛋白可启动二氢叶酸还原酶活性。参与多个过程，包括一氧化氮合酶活性的正调节；四氢生物蝶呤生物合成过程；和四氢叶酸相互转化。位于线粒体和细胞核中。以多种结构表达，包括消化系统；泌尿生殖系统；淋巴系统；外皮系统；和神经系统。该基因的人类直系同源物与急性淋巴细胞白血病有关。与几个人类基因同源，包括 DHFRP1（二氢叶酸还原酶假基因 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables dihydrofolate reductase activity. Involved in several processes, including positive regulation of nitric-oxide synthase activity; tetrahydrobiopterin biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]