2. Gene
  3. Lgr5 - leucine rich repeat containing G protein coupled receptor 5 Gene

Lgr5 - leucine rich repeat containing G protein coupled receptor 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: FEX; Gpr49

基因 ID: 14160 | 基因类型: protein coding

关于 Lgr5

功能概要

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]

Lgr5 基因产物(1)

mRNA Protein Name
NM_010195.2 NP_034325.2 leucine-rich repeat-containing G-protein coupled receptor 5 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transmembrane signaling receptor activity IDA
IDA: 通过直接分析推断
21727895 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within epithelial cell proliferation involved in renal tubule morphogenesis IGI
IGI: 通过遗传相互作用推断
24680895 MGI
acts upstream of or within hair follicle development IGI
IGI: 通过遗传相互作用推断
24680895 MGI
acts upstream of or within inner ear development IDA
IDA: 通过直接分析推断
21795542 MGI
acts upstream of or within oocyte differentiation IMP
IMP: 通过突变表型推断
25158167 MGI
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
21727895 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
25535395 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

leucine-rich repeat-containing G-protein coupled receptor 5

G protein-coupled receptor 49

follicle expressed hormone

orphan G-protein coupled receptor FEX

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99406 Petosemtamab Degrader 99.94% Phase 3
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10810 QPH-FR Inhibitor 98.96% 否
HY-148918 E722-2648 Inhibitor / 否
HY-RS07619 LGR5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20763 Lgr5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27277 Lgr5 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991454 Anti-LGR5/GPR49 Antibody (18G7H6A3) Inhibitor / 否
HY-P99406A Petosemtamab (FUT8-KO) / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lgr5 NCBI NCBI:8549
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