2. Gene
  3. Foxa2 - forkhead box A2 Gene

Foxa2 - forkhead box A2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hnf3b; Tcf3b; Hnf-3b; Tcf-3b; HNF3beta; HNF3-beta

基因 ID: 15376 | 基因类型: protein coding

关于 Foxa2

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of detection of glucose; negative regulation of Glucokinase activity; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of neuron differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; endoderm; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Apr 2022]

Foxa2 基因产物(3)

mRNA Protein Name
NM_001291065.1 NP_001277994.1 hepatocyte nuclear factor 3-beta isoform a
NM_001291067.1 NP_001277996.1 hepatocyte nuclear factor 3-beta isoform c
NM_010446.3 NP_034576.2 hepatocyte nuclear factor 3-beta isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11875061 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11914369 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10859308 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11875061 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12488434 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
22780989 MGI
enables double-stranded DNA binding IGI
IGI: 通过遗传相互作用推断
23117660 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20609350 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11914369 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
25446530 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
18076286 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
10498685 MGI
acts upstream of or within anatomical structure morphogenesis IGI
IGI: 通过遗传相互作用推断
9226455 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
10498685 MGI
acts upstream of or within cell development IMP
IMP: 通过突变表型推断
15680365 MGI
acts upstream of or within cell differentiation in hindbrain IGI
IGI: 通过遗传相互作用推断
17922007 MGI
acts upstream of or within cell differentiation in hindbrain IMP
IMP: 通过突变表型推断
17922007 MGI
acts upstream of or within cell fate specification IDA
IDA: 通过直接分析推断
18076286 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: 通过直接分析推断
15219627 MGI
acts upstream of or within connective tissue development IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
18076286 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: 通过直接分析推断
18590716 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: 通过遗传相互作用推断
9226455 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: 通过遗传相互作用推断
10498685 MGI
acts upstream of or within ectoderm formation IGI
IGI: 通过遗传相互作用推断
10498685 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: 通过突变表型推断
15680365 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: 通过遗传相互作用推断
15668254 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
29659575 MGI
involved in glucose mediated signaling pathway IDA
IDA: 通过直接分析推断
11875061 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9152011 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
15668254 MGI
acts upstream of or within lung epithelial cell differentiation IGI
IGI: 通过遗传相互作用推断
15668254 MGI
acts upstream of mesendoderm development IMP
IMP: 通过突变表型推断
26494787 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
17922007 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11875061 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within neuron differentiation IGI
IGI: 通过遗传相互作用推断
17922007 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
17922007 MGI
acts upstream of or within neuron fate specification IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within neuron fate specification IMP
IMP: 通过突变表型推断
17922007 MGI
acts upstream of or within pattern specification process IGI
IGI: 通过遗传相互作用推断
10498685 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
11291865 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
17596284 MGI
involved in positive regulation of embryonic development IMP
IMP: 通过突变表型推断
11291865 MGI
involved in positive regulation of gastrulation IMP
IMP: 通过突变表型推断
11291865 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
17922007 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10859308 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11875061 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15539431 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9152011 MGI
involved in positive regulation of transcription by RNA polymerase III IMP
IMP: 通过突变表型推断
15737987 MGI
acts upstream of or within primitive streak formation IMP
IMP: 通过突变表型推断
11291865 MGI
involved in primitive streak formation IMP
IMP: 通过突变表型推断
11291865 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12488434 MGI
acts upstream of or within regulation of gene expression IGI
IGI: 通过遗传相互作用推断
17596284 MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
11875061 MGI
acts upstream of or within regulation of lipid metabolic process IDA
IDA: 通过直接分析推断
22737085 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: 通过突变表型推断
22737085 MGI
acts upstream of or within regulation of steroid metabolic process IDA
IDA: 通过直接分析推断
22737085 MGI
acts upstream of or within regulation of steroid metabolic process IMP
IMP: 通过突变表型推断
22737085 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: 通过直接分析推断
18462699 MGI
acts upstream of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
23383217 MGI
acts upstream of or within somite rostral/caudal axis specification IMP
IMP: 通过突变表型推断
11291865 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10859308 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
8813084 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
26494787 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte nuclear factor 3-beta

HNF-3-beta

forkhead box protein A2

hepatocyte nuclear factor 3 beta (winged helix transcription factor)

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05037 FOXA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174679 Human FOXA2 mRNA / 否
HY-RS18820 Foxa2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25310 Foxa2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Foxa2 NCBI NCBI:3170
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z