1. Gene
  2. Mal - myelin and lymphocyte protein, T cell differentiation protein Gene

Mal - myelin and lymphocyte protein, T cell differentiation protein Gene

种属: Mus musculus

同用名: Mpv17; Vip17

基因 ID: 17153 | 基因类型: protein coding

关于 Mal

功能概要

This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Mal 基因产物(2)

mRNA Protein Name
NM_001171187.1 NP_001164658.1 myelin and lymphocyte protein isoform 2
NM_010762.5 NP_034892.1 myelin and lymphocyte protein isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of central nervous system myelination IMP
IMP: 通过突变表型推断
15337780 MGI
involved in myelination IMP
IMP: 通过突变表型推断
11032882 MGI
involved in protein insertion into plasma membrane IMP
IMP: 通过突变表型推断
22323295 MGI
involved in protein localization to paranode region of axon IMP
IMP: 通过突变表型推断
15337780 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in apical plasma membrane IDA
IDA: 通过直接分析推断
11032882 MGI
is active in hinge region between urothelial plaques of apical plasma membrane IMP
IMP: 通过突变表型推断
22323295 MGI
is active in membrane raft IDA
IDA: 通过直接分析推断
22323295 MGI
is active in plasma membrane raft IMP
IMP: 通过突变表型推断
15337780 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

myelin and lymphocyte protein

T-lymphocyte maturation-associated protein

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mal NCBI NCBI:4118
Canis familiaris Mal NCBI NCBI:403933
Macaca fascicularis Mal NCBI NCBI:101926035
Susscrofa domestica Mal NCBI
Rattus norvegicus Mal NCBI NCBI:25263
Macaca mulatta Mal NCBI NCBI:703532