2. Gene
  3. Mbd2 - methyl-CpG binding domain protein 2 Gene

Mbd2 - methyl-CpG binding domain protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MBD2a

基因 ID: 17191 | 基因类型: protein coding

关于 Mbd2

功能概要

Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including maternal behavior; negative regulation of transcription by RNA polymerase II; and positive regulation of Wnt signaling pathway. Located in cytoplasm; heterochromatin; and nucleus. Part of histone deacetylase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb ectoderm; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mbd2 基因产物(2)

mRNA Protein Name
NM_001311071.1 NP_001298000.1 methyl-CpG-binding domain protein 2 isoform 2
NM_010773.2 NP_034903.2 methyl-CpG-binding domain protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9774669 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16608912 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23335972 MGI
enables mRNA binding IDA
IDA: 通过直接分析推断
15342650 MGI
enables methyl-CpG binding IDA
IDA: 通过直接分析推断
15342650 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23335972 MGI
enables siRNA binding IDA
IDA: 通过直接分析推断
15342650 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
18644872 MGI
acts upstream of or within maternal behavior IMP
IMP: 通过突变表型推断
11274056 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11242117 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
18644872 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: 通过突变表型推断
11274056 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18644872 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
9774669 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17546630 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
14519686 MGI
part of histone deacetylase complex IDA
IDA: 通过直接分析推断
11274056 MGI
NOT located in nucleolus IDA
IDA: 通过直接分析推断
17546630 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9774669 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

methyl-CpG-binding domain protein 2

methyl-CpG-binding protein MBD2

testis-specific methyl-CpG binding protein 2

Mbd2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Mbd2 Q9Z2E1 Mbd2 Mus musculus Q9Z2E1
Anti Tag CoIP
23335972
种属内
Mbd2 Q9Z2E1 CHD4 Homo sapiens F5GWX5
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 GATAD2B Homo sapiens Q8WXI9
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 GATAD2A Homo sapiens Q86YP4
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 DHX30 Homo sapiens Q7L2E3-2
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 DHX36 Homo sapiens Q9H2U1
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 Mbd2 Mus musculus Q9Z2E1
Pull Down
23335972
种属内
Mbd2 Q9Z2E1 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
26496610
种属内
Mbd2 Q9Z2E1 CDK2AP1 Homo sapiens F5GZF0
Anti Tag CoIP
26496610
种属间
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
Anti Tag CoIP
23335972
种属间
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
IF
23335972
种属间
Mbd2 Q9Z2E1 Mecp2 Rattus norvegicus Q00566
Pull Down
23335972
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131031 KCC-07 99.97% 否
HY-RS03948 DPEP2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS08182 MBD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17814 Mbd2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18658 Dpep2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24283 Mbd2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mbd2 NCBI NCBI:8932
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