2. Gene
  3. Nsd1 - nuclear receptor-binding SET-domain protein 1 Gene

Nsd1 - nuclear receptor-binding SET-domain protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: KMT3B

基因 ID: 18193 | 基因类型: protein coding

关于 Nsd1

功能概要

Enables several functions, including histone-lysine N-methyltransferase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in histone methylation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within gastrulation with mouth forming second. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; long bone epiphysis; and retina. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nsd1 基因产物(19)

mRNA Protein Name
NM_001408698.1 NP_001395627.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408699.1 NP_001395628.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408700.1 NP_001395629.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408701.1 NP_001395630.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 3
NM_001408702.1 NP_001395631.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408703.1 NP_001395632.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408704.1 NP_001395633.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408705.1 NP_001395634.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408706.1 NP_001395635.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5
NM_001408707.1 NP_001395636.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408708.1 NP_001395637.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5
NM_001408709.1 NP_001395638.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408710.1 NP_001395639.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408711.1 NP_001395640.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408712.1 NP_001395641.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408713.1 NP_001395642.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7
NM_001408714.1 NP_001395643.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7
NM_001408715.1 NP_001395644.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 8
NM_008739.3 NP_032765.3 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
15522233 MGI
enables histone H3K36 methyltransferase activity IDA
IDA: 通过直接分析推断
12805229 MGI
enables histone H4K20 methyltransferase activity IDA
IDA: 通过直接分析推断
12805229 MGI
enables histone methyltransferase activity IDA
IDA: 通过直接分析推断
12805229 MGI
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
9628876 MGI
enables nuclear retinoic acid receptor binding IPI
IPI: 通过物理相互作用推断
9628876 MGI
enables nuclear retinoid X receptor binding IPI
IPI: 通过物理相互作用推断
9628876 MGI
enables nuclear thyroid hormone receptor binding IPI
IPI: 通过物理相互作用推断
9628876 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15169884 MGI
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
9628876 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
9628876 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within gastrulation with mouth forming second IMP
IMP: 通过突变表型推断
12805229 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9628876 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18157086 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase, H3 lysine-36 specific

H3-K36-HMTase

H4-K20-HMTase

NR-binding SET domain-containing protein

histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

nuclear receptor-binding SET domain-containing protein 1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134086 NSD-IN-2 Inhibitor 98.16% 否
HY-114340 LEM-14 98.02% 否
HY-121093 DC-S239 Inhibitor 99.73% 否
HY-125244 LEM-14-1189 Inhibitor 99.57% 否
HY-RS09587 NSD1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18628 Nsd1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25114 Nsd1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nsd1 NCBI NCBI:64324
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