2. Epigenetics
  3. Histone Methyltransferase
  4. LEM-14-1189

LEM-14-1189 是一种 LEM-14 (HY-114340) 衍生物，是一种 NSD 抑制剂，IC50 分别为 418 μM (NSD1)、111 μM (NSD2) 和 60 μM (NSD3)。NSD 是组蛋白赖氨酸甲基转移酶 (HMTase)，也是致癌蛋白和多种肿瘤的驱动因素。LEM-14-1189 可用于多发性骨髓瘤 (MM) 研究。

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LEM-14-1189 Chemical Structure

LEM-14-1189 Chemical Structure

CAS No. : 2987501-17-5

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LEM-14-1189 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LEM-14-1189, a LEM-14 (HY-114340) derivative, is a NSDs inhibitor with IC50s of 418 μM (NSD1), 111 μM (NSD2), and 60 μM (NSD3), respectively. The NSDs, histone lysine methyltransferases (HMTases), are oncoproteins, drivers of a number of tumors. LEM-14-1189 can be used for multiple myeloma (MM) research[1].

IC50 & Target

418 μM (NSD1), 111 μM (NSD2), and 60 μM (NSD3)[1]
分子量

682.81

Formula

C35H34N6O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LEM-14-1189 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LEM-14-11892987501-17-5Histone MethyltransferaseInhibitorinhibitorinhibit

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产品名称：
LEM-14-1189
目录号：
HY-125244
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