2. Gene
  3. Pomc - pro-opiomelanocortin-alpha Gene

Pomc - pro-opiomelanocortin-alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH

基因 ID: 18976 | 基因类型: protein coding

关于 Pomc

功能概要

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Pomc 基因产物(5)

mRNA Protein Name
NM_001278581.1 NP_001265510.1 pro-opiomelanocortin preproprotein
NM_001278582.1 NP_001265511.1 pro-opiomelanocortin preproprotein
NM_001278583.1 NP_001265512.1 pro-opiomelanocortin preproprotein
NM_001278584.1 NP_001265513.1 pro-opiomelanocortin preproprotein
NM_008895.4 NP_032921.1 pro-opiomelanocortin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
15467755 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16219686 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium-mediated signaling IMP
IMP: 通过突变表型推断
25096581 MGI
acts upstream of or within glucose homeostasis IMP
IMP: 通过突变表型推断
21184805 MGI
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
25096581 MGI
involved in positive regulation of oxytocin production IDA
IDA: 通过直接分析推断
25096581 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: 通过遗传相互作用推断
16243970 MGI
acts upstream of or within regulation of corticosterone secretion IMP
IMP: 通过突变表型推断
21184805 MGI
acts upstream of or within regulation of glycogen metabolic process IMP
IMP: 通过突变表型推断
21184805 MGI
involved in response to melanocyte-stimulating hormone IDA
IDA: 通过直接分析推断
25096581 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18388149 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
16219686 MGI
located in secretory granule IDA
IDA: 通过直接分析推断
1329576 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pro-opiomelanocortin

adrenal corticotropic hormone

adrenocorticotropic hormone

alpha-melanocyte stimulating hormone

beta-endorphin

corticotropin-like intermediary peptide

corticotropin-lipotropin

melanotropin gamma

met-enkephalin

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P0252 α-MSH Agonist 99.98% Phase 2
HY-N6733 Aphidicolin 99.93% Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P0252A α-MSH TFA Agonist 98.54% 否
HY-P2281A Atrial natriuretic factor (1-28) (human, porcine) TFA 98.07% 否
HY-P1210A Lys-γ3-MSH(human) TFA 97.44% 否
HY-P1922 γ-2-MSH (41-58), amide Agonist 98.80% 否
HY-P2281 Atrial natriuretic factor (1-28) (human, porcine) / 否
HY-117787 TUG-905 Agonist / 否
HY-121859 RU28362 / 否
HY-P1210 Lys-γ3-MSH(human) Agonist / 否
HY-P4779 Acetyl-ACTH (2-24) (human, bovine, rat) Modulator / 否
HY-P4782 Acetyl-ACTH (3-24) (human, bovine, rat) Modulator / 否
HY-P4784 Acetyl-ACTH (4-24) (human, bovine, rat) Modulator / 否
HY-P4786 Acetyl-ACTH (7-24) (human, bovine, rat) / 否
HY-P4985 γ3-MSH / 否
HY-RS10865 POMC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17248 Pomc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23702 Pomc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pomc NCBI NCBI:5443
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