2. Gene
  3. Nlgn1 - neuroligin 1 Gene

Nlgn1 - neuroligin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NL1; Nlg1; mKIAA1070; 6330415N05Rik

基因 ID: 192167 | 基因类型: protein coding

关于 Nlgn1

功能概要

Enables neurexin family protein binding activity. Involved in several processes, including positive regulation of transport; synapse organization; and synaptic vesicle cycle. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in external side of plasma membrane and synapse. Is integral component of plasma membrane. Part of receptor complex. Is active in glutamatergic synapse. Is expressed in blood vessel and brain. Used to study autism spectrum disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 基因产物(5)

mRNA Protein Name
NM_001163387.2 NP_001156859.1 neuroligin-1 isoform 2
NM_001357095.1 NP_001344024.1 neuroligin-1 isoform 3
NM_001357096.1 NP_001344025.1 neuroligin-1 isoform 4
NM_001357097.1 NP_001344026.1 neuroligin-1 isoform 4
NM_138666.4 NP_619607.2 neuroligin-1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neurexin family protein binding IMP
IMP: 通过突变表型推断
10892652 MGI
enables neurexin family protein binding IPI
IPI: 通过物理相互作用推断
12796785 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18084303 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in AMPA glutamate receptor clustering IDA
IDA: 通过直接分析推断
12796785 MGI
involved in AMPA glutamate receptor clustering IMP
IMP: 通过突变表型推断
21940442 MGI
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: 通过直接分析推断
12796785 MGI
involved in cytoskeletal matrix organization at active zone IMP
IMP: 通过突变表型推断
19628693 MGI
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
12796785 MGI
involved in excitatory synapse assembly IDA
IDA: 通过直接分析推断
22960622 MGI
involved in excitatory synapse assembly IMP
IMP: 通过突变表型推断
26440732 MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: 通过直接分析推断
12796785 MGI
NOT involved in inhibitory postsynaptic potential IMP
IMP: 通过突变表型推断
17582332 MGI
acts upstream of or within modulation of chemical synaptic transmission IGI
IGI: 通过遗传相互作用推断
16982420 MGI
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
23143522 MGI
involved in nervous system development IDA
IDA: 通过直接分析推断
10892652 MGI
involved in nervous system development IMP
IMP: 通过突变表型推断
28841651 MGI
involved in neurexin clustering involved in presynaptic membrane assembly IDA
IDA: 通过直接分析推断
12796785 MGI
involved in neuron cell-cell adhesion IDA
IDA: 通过直接分析推断
12796785 MGI
involved in positive regulation of circadian sleep/wake cycle, wakefulness IMP
IMP: 通过突变表型推断
23716671 MGI
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
23143522 MGI
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: 通过直接分析推断
17582332 MGI
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
23143522 MGI
acts upstream of or within positive regulation of synapse assembly IDA
IDA: 通过直接分析推断
21356198 MGI
involved in positive regulation of synaptic vesicle clustering IDA
IDA: 通过直接分析推断
15620359 MGI
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
19628693 MGI
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
19628693 MGI
involved in postsynaptic density protein 95 clustering IDA
IDA: 通过直接分析推断
12796785 MGI
involved in postsynaptic membrane assembly IDA
IDA: 通过直接分析推断
12796785 MGI
involved in postsynaptic specialization assembly IDA
IDA: 通过直接分析推断
15620359 MGI
involved in postsynaptic specialization assembly IMP
IMP: 通过突变表型推断
15620359 MGI
involved in presynaptic membrane assembly IDA
IDA: 通过直接分析推断
10892652 MGI
involved in protein localization to synapse IDA
IDA: 通过直接分析推断
15620359 MGI
involved in receptor localization to synapse IDA
IDA: 通过直接分析推断
12796785 MGI
involved in regulation of NMDA receptor activity IDA
IDA: 通过直接分析推断
17582332 MGI
involved in regulation of NMDA receptor activity IMP
IMP: 通过突变表型推断
23143522 MGI
involved in regulation of neuron differentiation IDA
IDA: 通过直接分析推断
10892652 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: 通过直接分析推断
32324534 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: 通过突变表型推断
32324534 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IGI
IGI: 通过遗传相互作用推断
16982420 MGI
acts upstream of synapse assembly IDA
IDA: 通过直接分析推断
21356198 MGI
involved in synapse assembly IDA
IDA: 通过直接分析推断
10892652 MGI
acts upstream of or within synapse organization IGI
IGI: 通过遗传相互作用推断
21788371 MGI
involved in synaptic membrane adhesion IDA
IDA: 通过直接分析推断
12796785 MGI
involved in synaptic membrane adhesion IMP
IMP: 通过突变表型推断
12796785 MGI
involved in synaptic vesicle clustering IDA
IDA: 通过直接分析推断
10892652 MGI
involved in synaptic vesicle targeting IMP
IMP: 通过突变表型推断
10892652 MGI
involved in terminal button organization IMP
IMP: 通过突变表型推断
19628693 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
23791195 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
20573900 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15620359 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
15620359 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
10892652 MGI
part of receptor complex IDA
IDA: 通过直接分析推断
12796785 MGI
located in synapse IDA
IDA: 通过直接分析推断
12202822 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuroligin-1

Nlgn1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Nlgn1 Q99K10 PTPRT Homo sapiens O14522
Anti Tag CoIP
19816407
种属间
Nlgn1 Q99K10 Kalrn Rattus norvegicus P97924-5
Anti Tag CoIP
31801062
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Nlgn1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74704 Neuroligin-1/NLGN1 Protein, Mouse (HEK293, His) Q99K10-1 (Q46-S697) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09339 NLGN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19024 Nlgn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25513 Nlgn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlgn1 NCBI NCBI:22871
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