2. Gene
  3. Trpv1 - transient receptor potential cation channel, subfamily V, member 1 Gene

Trpv1 - transient receptor potential cation channel, subfamily V, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Vr1; VR-1; OTRPC1; TRPV1beta; TRPV1alpha

基因 ID: 193034 | 基因类型: protein coding

关于 Trpv1

功能概要

Enables Calcium Channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain; ion transmembrane transport; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception; diet induced thermogenesis; and fever generation. Located in neuron projection and plasma membrane. Is expressed in central nervous system; cochlea; and dorsal root ganglion. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpv1 基因产物(1)

mRNA Protein Name
NM_001001445.2 NP_001001445.1 transient receptor potential cation channel subfamily V member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IDA
IDA: 通过直接分析推断
15489017 MGI
enables calcium channel activity IMP
IMP: 通过突变表型推断
10764638 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20351268 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18455988 MGI
enables temperature-gated ion channel activity IDA
IDA: 通过直接分析推断
18455988 MGI
enables temperature-gated ion channel activity IMP
IMP: 通过突变表型推断
22634729 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral response to pain IDA
IDA: 通过直接分析推断
18455988 MGI
acts upstream of or within behavioral response to pain IMP
IMP: 通过突变表型推断
17767493 MGI
acts upstream of or within calcium ion transport IDA
IDA: 通过直接分析推断
17194758 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
17767493 MGI
acts upstream of or within catagen IMP
IMP: 通过突变表型推断
16645591 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IDA
IDA: 通过直接分析推断
18272293 MGI
acts upstream of or within detection of chemical stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
18297068 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IGI
IGI: 通过遗传相互作用推断
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: 通过突变表型推断
22634729 MGI
acts upstream of or within detection of temperature stimulus involved in thermoception IDA
IDA: 通过直接分析推断
18455988 MGI
acts upstream of or within diet induced thermogenesis IMP
IMP: 通过突变表型推断
12161756 MGI
acts upstream of or within fever generation IMP
IMP: 通过突变表型推断
15763167 MGI
acts upstream of or within lipid metabolic process IMP
IMP: 通过突变表型推断
12161756 MGI
involved in monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
22634729 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23021218 MGI
acts upstream of or within peptide secretion IMP
IMP: 通过突变表型推断
18172555 MGI
acts upstream of or within response to heat IMP
IMP: 通过突变表型推断
10764638 MGI
acts upstream of or within response to pH IMP
IMP: 通过突变表型推断
10764638 MGI
acts upstream of or within response to pain IDA
IDA: 通过直接分析推断
18272293 MGI
acts upstream of or within response to pain IMP
IMP: 通过突变表型推断
18297068 MGI
acts upstream of or within sensory perception of mechanical stimulus IMP
IMP: 通过突变表型推断
12161756 MGI
acts upstream of or within sensory perception of pain IMP
IMP: 通过突变表型推断
10764638 MGI
acts upstream of or within sensory perception of taste IMP
IMP: 通过突变表型推断
17767493 MGI
acts upstream of or within smooth muscle contraction involved in micturition IMP
IMP: 通过突变表型推断
12161756 MGI
acts upstream of or within temperature homeostasis IMP
IMP: 通过突变表型推断
10764638 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: 通过突变表型推断
12161756 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
25775089 MGI
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
25775089 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
11466438 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
18455988 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
25775089 MGI
is active in postsynaptic membrane IMP
IMP: 通过突变表型推断
25775089 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transient receptor potential cation channel subfamily V member 1

capsaicin receptor

cation channel

deltaN-TRPv1

osm-9-like TRP channel 1

transient receptor potential cation channel V1

vanilloid receptor 1

vanilloid receptor subtype 1

相关产品

Approval
生物活性分子 (9)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10448 Capsaicin 99.88% 是
HY-N0172 Caffeic acid Inhibitor 99.92% 否
HY-10448A Capsaicin (Purity 65%) 99.20% 否
HY-10448R Capsaicin (Standard) 99.38% 否
HY-17568 Nonivamide Agonist 99.06% 否
HY-B1583 (Z)-Capsaicin 99.79% 是
HY-B1173 (+)-Camphor Inhibitor ≥98.0% 否
HY-124073 Dihydrocapsiate Agonist 99.33% 否
HY-16413 Protokylol hydrochloride Agonist / 否
Clinical Phase
生物活性分子 (11)
目录号 产品名 作用方式
纯度 Phase
HY-12777 Asivatrep Antagonist 95.76% Phase 3
HY-105285 Piromelatine 99.54% Phase 3
HY-132596 Tivanisiran Inhibitor 92.62% Phase 3
HY-10633 SB-705498 Antagonist 99.98% Phase 2
HY-137459 Vocacapsaicin Agonist / Phase 2
HY-12914 V116517 Antagonist / Phase 2
HY-137459A Vocacapsaicin hydrochloride Antagonist / Phase 2
HY-10634 AMG 517 Antagonist 99.97% Phase 1
HY-16935 Mavatrep Antagonist 99.67% Phase 1
HY-N8377 Capsiate Agonist 99.85% Phase 1
HY-12195 ABT-239 Antagonist 99.23% Phase 1
Pre-clinical Phase
生物活性分子 (118)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N2333 Resiniferatoxin Agonist 99.77% 否
HY-15640 Capsazepine ≥99.0% 否
HY-10863 Anandamide ≥99.0% 否
HY-N0285 Imperatorin 98.72% 否
HY-101736 AMG9810 Antagonist 99.76% 否
HY-12245 SB-366791 Antagonist 98.11% 否
HY-N0361 Dihydrocapsaicin 99.93% 否
HY-101507 Zerencotrep Inhibitor 99.47% 否
HY-N6825 Hydroxy-α-sanshool Agonist 99.57% 否
HY-107436 LE135 ≥99.0% 否
HY-19960 BCTC 99.66% 否
HY-N0447 8-Gingerol 99.82% 否
HY-103368 Eact Activator 98.86% 否
HY-157131 TRPV2-selective blocker 1 Inhibitor 99.84% 否
HY-P3467 (Thr4,Gly7)-Oxytocin 99.86% 否
HY-W020468 Linopirdine 99.90% 否
HY-108448 N-Oleoyldopamine Agonist 99.47% 否
HY-101448 TMI-1 99.57% 否
HY-18662 RQ-00203078 Antagonist 99.84% 否
HY-N8264 Moringin Agonist 99.95% 否
HY-N1471 Liquiritin apioside 99.60% 否
HY-N6962 α-Spinasterol 99.15% 否
HY-108460 A-784168 Inhibitor ≥99.0% 否
HY-100129 JNJ-17203212 Antagonist 99.94% 否
HY-144372 TRPV1 antagonist 3 Antagonist 98.97% 否
HY-101323 Olvanil Agonist ≥99.0% 否
HY-121636 Resolvin D2 Inhibitor 99.90% 否
HY-132596A Tivanisiran sodium 96.85% 否
HY-120963 N-Oleoyl Taurine ≥99.0% 否
HY-100668 JYL 1421 Antagonist 99.54% 否
HY-118785 MSP-3 Agonist 98.53% 否
HY-136363 MDR-652 Agonist 99.02% 否
HY-110018 N-Arachidonyldopamine Agonist 98.36% 否
HY-114017 Libvatrep Antagonist 99.54% 否
HY-120294 Chrysin 6-C-glucoside 8-C-arabinoside Inhibitor 99.11% 否
HY-W014394 Vanillyl butyl ether Agonist 99.67% 否
HY-101389 (R)-Methanandamide Agonist / 否
HY-10863S Anandamide-d8 99.90% 否
HY-120962 N-Arachidonoyl Taurine Activator ≥99.0% 否
HY-160900 RN-1665 Antagonist 99.93% 否
HY-108455 N-Palmitoyl dopamine 98.88% 否
HY-108458 SB 452533 Antagonist 99.11% 否
HY-109841 Oleoyl serotonin Inhibitor ≥99.0% 否
HY-12428 A-1165442 Antagonist 99.92% 否
HY-135882 OMDM-6 Agonist / 否
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% 否
HY-124001 N-Docosanoyl taurine Activator ≥99.0% 否
HY-131986 LASSBio-1135 Antagonist 99.05% 否
HY-103337 N-Arachidonoylserotonin ≥98.0% 否
HY-10635 ABT-102 Antagonist / 否
HY-121636S Resolvin D2-d5 Inhibitor ≥99.0% 否
HY-N7536 Voacangine 98.78% 否
HY-113654 AMG 7905 Antagonist / 否
HY-158110 Phenylcapsaicin Activator 99.77% 否
HY-10448S1 Capsaicin-d3 / 否
HY-10448S4 Capsaicin-d7 / 否
HY-108576 Linopirdine dihydrochloride Agonist / 否
HY-110145 MRS 1477 Modulator / 否
HY-110292 A-425619 Antagonist 99.96% 否
HY-111036 AMG0347 Antagonist / 否
HY-111038 Capsiconiate Agonist / 否
HY-111218 TRPV1 antagonist 5 Antagonist / 否
HY-113654A AMG 7905 TFA Antagonist 99.06% 否
HY-114630 Protokylol Agonist / 否
HY-118103R Coprostanol (Standard) / 否
HY-120174 SU200 / 否
HY-121080 AMG8163 Antagonist / 否
HY-124382 AS1928370 / 否
HY-128479 JYL-273 Agonist / 否
HY-135881 OMDM-5 Agonist / 否
HY-137988 Palvanil Modulator / 否
HY-147707 CB2 receptor antagonist 1 / 否
HY-148751 TRPV1 activator-1 Activator / 否
HY-148752 TRPV1 activator-2 Activator / 否
HY-150030 CB1/2 agonist 4 Agonist / 否
HY-157766 FAAH/TRPV1 blocker-1 Inhibitor / 否
HY-161273 TRPV1 antagonist 6 Antagonist / 否
HY-161420 TRPV1 antagonist 7 Antagonist / 否
HY-162856 TRPV1-IN-2 Inhibitor / 否
HY-162908 TRPV1/CB2 agonist 1 Agonist / 否
HY-170839 TRPV1-IN-3 Inhibitor / 否
HY-172774 TRPV1 antagonist 10 / 否
HY-174344 TRPV1 agonist-1 Agonist / 否
HY-174848 PQM-244 Modulator / 否
HY-176063 TRPV1 antagonist 11 / 否
HY-19589 JTS-653 Antagonist / 否
HY-N0361S Dihydrocapsaicin-d3 / 否
HY-N2941 Bisandrographolide C Activator / 否
HY-P10464 Tat-AKAP79 (326-336) Inhibitor / 否
HY-P10465 TRPV1-Tat Antagonist / 否
HY-P1175 L-R4W2 Antagonist / 否
HY-P1175A L-R4W2 TFA Antagonist / 否
HY-RS15121 TRPV1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W517163 MK-2295 Antagonist / 否
HY-W654381 N-Vanillylnonanamide-d3 / 否
HY-W790266 Polygodial pyridazine Agonist / 否
HY-10635A (S)-ABT-102 Antagonist / 否
HY-110091 TRPV1 antagonist 9 Antagonist / 否
HY-110209 AC4 Antagonist / 否
HY-117683 BCTP Antagonist / 否
HY-117922 JYL-79 Agonist / 否
HY-120476 JNJ-39729209 Inhibitor / 否
HY-121122 A778317 Antagonist / 否
HY-121465 Stearoyl Serotonin / 否
HY-123374 (Rac)-AMG 628 Antagonist / 否
HY-123428 MSK-195 Agonist / 否
HY-133166 A-889425 Antagonist / 否
HY-167868 DWP-05195 / 否
HY-16935S Mavatrep-d6 Antagonist / 否
HY-169780 (S)-AMG-628 Antagonist / 否
HY-N10612 Petasin / 否
HY-P10654 RhTx Activator / 否
HY-RS16501 Trpv1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22933 Trpv1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W554764 Cyclo(-asp-gly) Activator / 否
HY-W708469 Resolvin D2 methyl ester Inhibitor / 否
HY-W747573 N-Linolenoylethanolamine Agonist / 否
HY-W931056 AMG-628 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trpv1 NCBI NCBI:7442
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