2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. TRP Channel Opioid Receptor
  4. TRPV1 antagonist 11

TRPV1 antagonist 11 (compound 2ac) 是一种强效的 TRPV1 拮抗剂，IC50 为 29.3 nM。TRPV1 antagonist 11 是一种 μ-阿片受体 (MOR) 激动剂，Ki 为 60.3 nM。TRPV1 antagonist 11 是一种嘧啶哌嗪类化合物，通过拮抗 TRPV1 和刺激 MOR 发挥止痛作用。TRPV1 antagonist 11 在小鼠福尔马林诱发的疼痛模型中表现出有效的剂量依赖性抗伤害作用。

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TRPV1 antagonist 11 Chemical Structure

TRPV1 antagonist 11 Chemical Structure

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TRPV1 antagonist 11 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

查看 Opioid Receptor 亚型特异性产品:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

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  • 参考文献

生物活性

TRPV1 antagonist 11 (compound 2ac) is a potent TRPV1 antagonist with an IC50 of 29.3 nM. TRPV1 antagonist 11 is a potent μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. TRPV1 antagonist 11, a pyrimidine piperazine, exhibits pain relieving effects by antagonizing TRPV1 and stimulating MOR. TRPV1 antagonist 11 shows a potent, dose-dependent anti-nociceptive effect in a Formalin-induced pain model in mice[1].

IC50 & Target[1]

TRPV1

29.3 nM (IC50)

μ Opioid Receptor/MOR

60.3 nM (Ki)

分子量

539.67

Formula

C31H37N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPV1 antagonist 11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPV1 antagonist 11TRP ChannelOpioid ReceptorTransient receptor potential channelspyrimidine piperazinepainInhibitorinhibitorinhibit

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TRPV1 antagonist 11
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