1. Gene
  2. GPC5 - glypican 5 Gene

GPC5 - glypican 5 Gene

中文名称:磷脂球蛋白聚糖 5

种属: Homo sapiens

基因 ID: 2262 | 基因类型: protein coding

关于 GPC5

Cytogenetic location: 13q31.3 Genomic coordinates (GRCh38): 13:91,398,621-92,867,237 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 83 phenotypes. Biased expression in brain (RPKM 1.8), testis (RPKM 1.4) and 7 other tissues.

功能概要

细胞表面硫酸乙酰肝素蛋白聚糖由膜相关蛋白核心组成,该核心被可变数量的硫酸乙酰肝素链取代。磷脂酰肌醇蛋白聚糖相关的完整膜蛋白多糖家族 (GRIPS) 的成员包含一个通过糖基磷脂酰肌醇键固定在细胞质膜上的核心蛋白。这些蛋白质可能在控制细胞分裂和生长调节中发挥作用。[RefSeq 提供,2008 年 7 月]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

GPC5 基因产物(1)

mRNA Protein Name
NM_004466.6 NP_004457.1 glypican-5 precursor

GPC5 蛋白结构

Glypican

Glypican: Glypican (11 - 572)

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  • 500
  • 572 a.a.
蛋白主名 其他名称

glypican-5

bA93M14.1

重组 GPC5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73079 Glypican-5/GPC5 Protein, Human (sf9, His) P78333 (E25-T554) ≥95%

关联疾病

疾病名称 别名
Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis

Keipert Syndrome

Nasodigitoacoustic Syndrome

KPTS

Nasodigitoacoustic Syndrome, Formerly

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1

Simpson-Golabi-Behmel Syndrome

SGBS1

Golabi-Rosen Syndrome

Simpson Dysmorphia Syndrome

Sgbs

Bulldog Syndrome

Dgsx

Sdys

Dysplasia Gigantism Syndrome, X-Linked

X-Linked Dysplasia Gigantism Syndrome

Dgsx Golabi-Rosen Syndrome

Sara Angers Syndrome

Sgb Syndrome

Mental Retardation-Overgrowth Syndrome

Simpson Dysplasia Syndrome

Simpson Syndrome

Simpson-Golabi-Behmel Syndrome 1

Dysplasia Gigantism Syndrome X-Linked

Hereditary Multiple Exostoses

Multiple Congenital Exostosis

Hereditary Multiple Exostoses 1

Hereditary Multiple Exostoses 2

Hereditary Multiple Exostoses 3

Multiple Exostosis Syndromes

Multiple Ostechondromas

Osteochondromatosis Syndrome

Exostoses Multiple Hereditary

Exostoses, Multiple Hereditary

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Feingold Syndrome 1

Feingold Syndrome

Oculodigitoesophagoduodenal Syndrome

Oded Syndrome

Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum

FGLDS1

Mmt Syndrome

Brunner-Winter Syndrome

Feingold Syndrome Type 1

Oded

Moded

Fglds

Microcephaly-Digital Anomalies-Normal Intelligence Syndrome

Moded Syndrome

Oculo-Digito-Esophageal-Duodenal Syndrome

Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome

Microcephaly And Digital Abnormalities With Normal Intelligence

Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum

Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome

Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome

Oculo-Digito-Esophagoduodental Syndrome

Fs

Mmt

Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome

Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome

Brunner-Winter Syndrome Type 1

Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1

Fs1

Mmt Type 1

Moded Syndrome Type 1

Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1

Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1

Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1

Oded Syndrome Type 1

Oculo-Digito-Esophageal-Duodenal Syndrome Type 1

Feingold Syndrome, Type 1

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Rhabdomyosarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GPC5 RGD RGD:1308835
Canis familiaris GPC5 VGNC VGNC:49903
Macaca mulatta GPC5 VGNC VGNC:73119
Felis catus GPC5 VGNC VGNC:102214
Bos taurus GPC5 VGNC VGNC:29527
Mus musculus GPC5 MGD MGI:1194894
Others GPC5 NCBI