2. Gene
  3. Dhfr - dihydrofolate reductase Gene

Dhfr - dihydrofolate reductase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：二氢叶酸还原酶

种属: Rattus norvegicus

同用名: Dhfr1

基因 ID: 24312 | 基因类型: protein coding

关于 Dhfr

Primary_assembly 2: 23,586,031-23,613,713 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 356 orthologues, 1 paralogue and is associated with 25 phenotypes. Biased expression in Kidney (RPKM 45.8), Liver (RPKM 427.1) and 5 other tissues.

功能概要

该基因编码的蛋白可启动 NADP 绑定活动；二氢叶酸还原酶活性；和二氢叶酸结合活性。参与几个过程，包括轴突再生；含叶酸的复合代谢过程；和对甲氨蝶呤的反应。位于线粒体中。该基因的人类直系同源物与急性淋巴细胞白血病有关。与几个人类基因同源，包括 DHFR2（二氢叶酸还原酶 2）和 DHFRP1（二氢叶酸还原酶假基因 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables NADP binding activity; dihydrofolate reductase activity; and dihydrofolic acid binding activity. Involved in several processes, including axon regeneration; folic acid-containing compound metabolic process; and response to methotrexate. Located in mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR2 (dihydrofolate reductase 2) and DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]

Dhfr 基因产物(1)

mRNA Protein Name
NM_130400.2 NP_569084.1 dihydrofolate reductase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADP binding IDA
IDA: 通过直接分析推断
3970530 RGD
enables dihydrofolate reductase activity IDA
IDA: 通过直接分析推断
3970530 RGD
enables dihydrofolate reductase activity IMP
IMP: 通过突变表型推断
6162551 RGD
enables dihydrofolic acid binding IDA
IDA: 通过直接分析推断
3970530 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axon regeneration IMP
IMP: 通过突变表型推断
20424322 RGD
involved in dihydrofolate metabolic process IDA
IDA: 通过直接分析推断
3970530 RGD
involved in folic acid metabolic process IDA
IDA: 通过直接分析推断
20424322 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
15983034 RGD
involved in tetrahydrofolate biosynthetic process IDA
IDA: 通过直接分析推断
11502523 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25980602 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
25980602 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Dhfr 蛋白结构

DHFR

DHFR: cd00209 (4 - 183)

  • 0
  • 100
  • 187 a.a.
蛋白主名 其他名称

dihydrofolate reductase

Dihydrofolate reductase 1 (active)

相关产品

Approval
生物活性分子 (13)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10820 Pemetrexed Inducer 99.95% 否
HY-10820A Pemetrexed disodium Inducer 99.79% 否
HY-10446 Pralatrexate Inducer 99.23% 是
HY-18062 Pyrimethamine 99.99% 是
HY-10373 Trimetrexate Inhibitor 99.60% 否
HY-B0806 Proguanil Inhibitor 99.84% 否
HY-13781 Pemetrexed disodium hemipenta hydrate Inducer 99.78% 否
HY-10820B Pemetrexed disodium heptahydrate 99.97% 否
HY-I0447 4-Aminosalicylic acid Inhibitor 98.27% 是
HY-I0447A Sodium 4-aminosalicylate dihydrate Inhibitor 99.95% 是
HY-B0806A Proguanil hydrochloride Inhibitor 99.21% 否
HY-10373A Trimetrexate trihydrochloride Inhibitor / 否
HY-10373B Trimetrexate isethionate Inhibitor / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-14518 Aminopterin Antagonist 98.0% Phase 2
HY-10824 Talotrexin 99.27% Phase 2
HY-106434 Piritrexim Inhibitor 99.68% Phase 2
HY-10824A Talotrexin monoammonium Inhibitor / Phase 2
HY-10824B Talotrexin ammonium Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (79)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116387 WR99210 Inhibitor 99.10% 否
HY-126316 Zapalog Modulator 99.62% 否
HY-W587663 4′-DTMP Inhibitor 97.33% 否
HY-W003561 DHFR-IN-3 Inhibitor 99.48% 否
HY-18062S Pyrimethamine-d3 99.90% 否
HY-107033 Tetroxoprim Inhibitor 99.32% 否
HY-116387A WR99210 hydrochloride Inhibitor 98.34% 否
HY-139743 Aditoprime Inhibitor 99.68% 否
HY-151159 DHFR-IN-4 Inhibitor 99.19% 否
HY-RS03730 DHFR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-137439 Fanotaprim 98.89% 否
HY-153007 DHFR-IN-5 Inhibitor 99.27% 否
HY-162475 Fluorofolin Inhibitor / 否
HY-B0806AS1 Proguanil-d6 hydrochloride Inhibitor 98.73% 否
HY-B1902 Diaveridine 99.79% 否
HY-149459A Phototrexate Inhibitor 96.70% 否
HY-22252 4-Aminosalicylic acid hemicalcium Inhibitor / 否
HY-10820AS Pemetrexed-d5 disodium Inducer / 否
HY-10820S Pemetrexed-d5 / 否
HY-116039 Epiroprim Inhibitor / 否
HY-117000A D-156844 hydrochloride / 否
HY-117791 (R)-Pralatrexate / 否
HY-121207 Denopterin Inhibitor / 否
HY-122045 CB 3705 Inhibitor / 否
HY-122289 Metioprim Inhibitor / 否
HY-143236 DHFR-IN-1 Inhibitor / 否
HY-147661 DHFR-IN-2 Inhibitor / 否
HY-149200 Lysine-methotrexate / 否
HY-149632 EGFR/HER2/DHFR-IN-2 Inhibitor / 否
HY-149633 EGFR/HER2/DHFR-IN-3 / 否
HY-149958 Antileishmanial agent-17 Inhibitor / 否
HY-151154 EGFR/HER2/DHFR-IN-1 Inhibitor / 否
HY-151156 EGFR/HER2-IN-6 / 否
HY-151158 EGFR/HER2-IN-7 Inhibitor / 否
HY-151161 EGFR/HER2-IN-8 Inhibitor / 否
HY-151458 VEGFR-2/DHFR-IN-1 Inhibitor / 否
HY-151459 VEGFR-2/DHFR-IN-2 Inhibitor / 否
HY-154807 DQn-1 Inhibitor / 否
HY-156122 DHFR-IN-8 Inhibitor / 否
HY-156123 DHFR-IN-9 Inhibitor / 否
HY-156859 NSC309401 dihydrochloride Inhibitor / 否
HY-162358 DHFR-IN-17 Inhibitor / 否
HY-163722 EGFR/DHFR-IN-1 Inhibitor / 否
HY-168648 DNA Gyrase/DHFR-IN-1 Inhibitor / 否
HY-168918 Insecticidal agent 19 Inhibitor / 否
HY-172897 EGFR/DHFR-IN-2 / 否
HY-173220 DHFR-IN-23 / 否
HY-176557 NCI677397 / 否
HY-19095 TNP-351 / 否
HY-19885 AR-102 Inhibitor / 否
HY-B0806S1 Proguanil-d4 / 否
HY-E70522 Dihydrofolate reductase / 否
HY-N10791 Neobritannilactone B / 否
HY-RS03731 Dhfr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03732 Dhfr Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W769288 Pemetrexed disodium-13C5 / 否
HY-115836 DDPO Inhibitor / 否
HY-118251 PD130883 Inhibitor / 否
HY-119613 Clociguanil Inhibitor / 否
HY-143408 OYYF-175 Inhibitor / 否
HY-149699 DHFR-IN-12 Inhibitor / 否
HY-153007A DHFR-IN-5 hydrochloride Inhibitor / 否
HY-156412 DHFR-IN-10 Inhibitor / 否
HY-156414 DHFR-IN-11 Inhibitor / 否
HY-156859A NSC309401 Inhibitor / 否
HY-159899 DHFR-IN-22 Inhibitor / 否
HY-161010 DHFR-IN-13 Inhibitor / 否
HY-161063 DHFR-IN-14 Inhibitor / 否
HY-161064 DHFR-IN-15 Inhibitor / 否
HY-161292 DHFR-IN-16 Inhibitor / 否
HY-162656 DHFR-IN-19 Inhibitor / 否
HY-163725 DHFR-IN-18 Inhibitor / 否
HY-168069 DHFR-IN-20 Inhibitor / 否
HY-169211 DHFR-IN-21 Inhibitor / 否
HY-169790 Phomarin Inhibitor / 否
HY-177337 N-Didesmethyladitoprim Inhibitor / 否
HY-B0806AS Proguanil-d4 hydrochloride Inhibitor / 否
HY-B1902S Diaveridine-d6 / 否
HY-N3764 Diosbulbin C Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dhfr NCBI NCBI:1719
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