Dhfr - dihydrofolate reductase Gene

中文名称：二氢叶酸还原酶

种属: Rattus norvegicus

同用名: Dhfr1

关于 Dhfr

功能概要

该基因编码的蛋白可启动 NADP 绑定活动；二氢叶酸还原酶活性；和二氢叶酸结合活性。参与几个过程，包括轴突再生；含叶酸的复合代谢过程；和对甲氨蝶呤的反应。位于线粒体中。该基因的人类直系同源物与急性淋巴细胞白血病有关。与几个人类基因同源，包括 DHFR2（二氢叶酸还原酶 2）和 DHFRP1（二氢叶酸还原酶假基因 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables NADP binding activity; dihydrofolate reductase activity; and dihydrofolic acid binding activity. Involved in several processes, including axon regeneration; folic acid-containing compound metabolic process; and response to methotrexate. Located in mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR2 (dihydrofolate reductase 2) and DHFRP1 (dihydrofolate reductase pseudogene 1). [provided by Alliance of Genome Resources, Apr 2022]