Igf2 - insulin-like growth factor 2 Gene

种属: Rattus norvegicus

同用名: IGFII; RNIGF2

基因 ID: 24483 | 基因类型: protein coding

关于 Igf2

功能概要

Predicted to enable protein serine/threonine kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (Insulin like growth factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Igf2 基因产物(3)

mRNA	Protein	Name
NM_001190162.1	NP_001177091.1	insulin-like growth factor II isoform 2 preproprotein
NM_001190163.1	NP_001177092.1	insulin-like growth factor II isoform 2 preproprotein
NM_031511.2	NP_113699.2	insulin-like growth factor II isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	2538475	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	20695079	RGD
involved in female pregnancy	IEP IEP: 通过表达模式推断	19776249	RGD
involved in memory	IMP IMP: 通过突变表型推断	21270887	RGD
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	9021955	RGD
involved in positive regulation of angiogenesis	IGI IGI: 通过遗传相互作用推断	28735866	RGD
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: 通过遗传相互作用推断	28735866	RGD
involved in positive regulation of steroid hormone biosynthetic process	IDA IDA: 通过直接分析推断	17023532	RGD
involved in positive regulation of vascular endothelial cell proliferation	IGI IGI: 通过遗传相互作用推断	28735866	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	18946176	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	18505416	RGD
involved in response to nicotine	IDA IDA: 通过直接分析推断	19494366	RGD
involved in response to nicotine	IEP IEP: 通过表达模式推断	19494366	RGD
involved in response to nutrient levels	IEP IEP: 通过表达模式推断	17626604	RGD
involved in response to organic cyclic compound	IDA IDA: 通过直接分析推断	17407073	RGD
involved in response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	18778817	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	6390212	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

insulin-like growth factor II

IGF-II	Insulin-like growth factor II (somatomedin A)
MSA	insulin-like growth factor II (IGF-II)
multiplication-stimulating activity	multiplication-stimulating polypeptide

相关产品

Clinical Phase

抗体抑制剂 (2)

目录号	产品名	作用方式	纯度	Phase
HY-P99274	Xentuzumab	Antagonist	99.71%	Phase 2
HY-P99867	Dusigitumab		96.37%	Phase 2

Pre-clinical Phase

生物活性分子 (24)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-153274	CWI1-2	Inducer	98.18%	否
HY-144873	AVJ16	Inducer	99.60%	否
HY-115449	Chromeceptin		99.80%	否
HY-153274A	CWI1-2 hydrochloride	Inducer	98.27%	否
HY-156110	IGF2BP1-IN-1	Inhibitor	99.94%	否
HY-174228	I3IN-002		99.35%	否
HY-176471	IGF2BP3-IN-1	Inhibitor	98.25%	否
HY-RS06622	IGF2R Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS06618	IGF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS06619	IGF2BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS06620	IGF2BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17518	Igf2bp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS06621	IGF2BP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS06839	INS-IGF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-174653	Human IGF2 mRNA		/	否
HY-RS16571	Igf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16822	Igf2bp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS16849	Igf2bp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17981	Igf2r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23004	Igf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23262	Igf2bp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23290	Igf2bp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23975	Igf2bp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24452	Igf2r Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

抗体抑制剂 (3)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99294	Ganitumab	Inhibitor	96.00%	否
HY-P99284	Dalotuzumab		97.43%	否
HY-P991253	BIIB022	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Igf2	NCBI	NCBI:3481
Macaca mulatta	Igf2	NCBI	NCBI:710802

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