2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Xentuzumab

Xentuzumab  (Synonyms: BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody)

目录号: HY-P99274 纯度: 99.71%
COA

摩尔计算器

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) 是重组的人源单克隆抗体，靶向 IGF 配体 IGF1 和 IGF2。Xentuzumab 抑制 IGF1 和 IGF2 的生长促进信号，抑制 AKT 的激活。

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Xentuzumab Chemical Structure

Xentuzumab Chemical Structure

CAS No. : 1417158-65-6

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规格 价格 是否有货 数量
1 mg ￥3500
In-stock
5 mg ￥9500
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Customer Review

Xentuzumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation[1].

IC50 & Target

IGF1, IGF2[1]
体外研究
(In Vitro)

Xentuzumab (0.01-1 mM; 96 h) inhibits IGF type 1 receptor signaling and (0.1 μM; 48 h) AKT serine/threonine kinase (AKT) phosphorylation in VCaP, DuCaP, and MDA PCa 2b cell in a dose-dependent manner[1].
Xentuzumab (0.01-1 mM; 5-10 d) losses of antiproliferative activity against PTEN-null LNCaP or PC-3 cells when PTEN knockdown[1].
Xentuzumab (1 μM; 24-72 h) arrests cell cycle at sub-G1 phase and induces apoptosis in VCaP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xentuzumab 相关抗体:

Western Blot Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 0.1 μM
Incubation Time: 24 h and 48 h
Result: Increased in cleaved caspase 3/7 and PARP.
Decreased the level of phosphorylation of FoxO3a (S253)/FoxO1 (T24).

Cell Cycle Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 1 μM
Incubation Time: 24 h, 48 h, and 72 h
Result: Increased in cleaved caspase 3/7 and induces cell apoptosis.
Increased the sub-G1 cell population.
体内研究
(In Vivo)

Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)[1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose
Result: Resulted in significant reductions in tumor volume.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.71%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Xentuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xentuzumab1417158-65-6BI 836845 Anti-Human IGF1 and IGF2 Recombinant AntibodyBI836845BI-836845IGF-1RInsulin-like growth factor-1 receptorVCaPDuCaPMDA PCa 2bPTEN-null LNCaPInhibitorinhibitorinhibit

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