Csf1r - colony stimulating factor 1 receptor Gene

中文名称：集落刺激因子1 受体

种属: Rattus norvegicus

同用名: c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R

关于 Csf1r

功能概要

预计该基因编码的蛋白具有多种功能，包括巨噬细胞集落刺激因子受体活性；蛋白质同二聚化活性；和蛋白磷酸酶结合活性。参与多个过程，包括神经系统发育；破骨细胞分化的正调节；和调节骨吸收。预测位于细胞表面；核质；和质膜。预计是 CSF1-CSF1R 复合体和受体复合体的一部分。预计是质膜的组成部分。用于研究抗基底膜肾小球肾炎；骨发育疾病；不孕症;和淋巴细胞减少症。该基因的人类直系同源物与轴突球体和色素性胶质细胞和肾细胞癌的成人发病白质脑病有关。与人 CSF1R（集落刺激因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of osteoclast differentiation; and regulation of bone resorption. Predicted to be located in cell surface; nucleoplasm; and plasma membrane. Predicted to be part of CSF1-CSF1R complex and receptor complex. Predicted to be integral component of plasma membrane. Used to study anti-basement membrane glomerulonephritis; bone development disease; infertility; and lymphopenia. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]