Iluzanebart  (Synonyms: VGL101)

Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP)^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

TREM-2

Iluzanebart (0.1 nM-1 μM, 45 min) 激活 TREM2 信号通路，在 HEK293T、hMDM 和 iMGL 细胞中增强 SYK 和 DAP12 的磷酸化（HEK293T、hMDM 和 iMGL 中 SYK 磷酸化的 EC₅₀ 分别为 0.27 nM、4.77 nM 和 0.63 nM)^[1]。
Iluzanebart (10 µg/mL, 48-96 h) 恢复 PLX5622 (HY-114153) 诱导的细胞融合和 hMDM 和 iMGL 细胞的分枝形态，并增加细胞活力^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iluzanebart (1-200 mg/kg, ip, single dose) 可在表达人类 TREM2 的转基因小鼠模型中提高小胶质细胞增殖和 CSF1R 水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

54209  [NCBI]

Q9NZC2-1

144.92 kDa

2733621-19-5

液体

Colorless to light yellow

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Immobilized TREM-2 Protein, Human can bind Iluzanebart. The EC₅₀ for this effect is 178.6 ng/mL.

• [1]. Larson KC, et al., Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. J Neuroinflammation. 2025 Jan 31;22(1):26.  [Content Brief]