2. Gene
  3. RET - ret proto-oncogene Gene

RET - ret proto-oncogene Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ret 原癌基因

种属: Canis lupus familiaris (sub-species: familiaris)

基因 ID: 403494 | 基因类型: protein coding

关于 RET

Primary_assembly 28: 4,126,037-4,174,867 reverse strand.ROS_Cfam_1.0:CM025127.1

This gene has 3 transcripts (splice variants), 205 orthologues and 54 paralogues.

RET 基因产物(1)

mRNA Protein Name
NM_001197099.1 NP_001184028.1 proto-oncogene tyrosine-protein kinase receptor Ret

RET 蛋白结构

RET_CLD1

RET_CLD1: pfam17756 (30 - 156)

Cadherin

Cadherin: pfam00028 (175 - 264)

RET_CLD3

RET_CLD3: pfam17812 (268 - 382)

RET_CLD4

RET_CLD4: pfam17813 (407 - 509)

PTKc_RET

PTKc_RET: cd05045 (727 - 1016)

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  • 1119 a.a.
蛋白主名 其他名称

proto-oncogene tyrosine-protein kinase receptor Ret

ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

ret tyrosine kinase

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10981 Lenvatinib Inhibitor 99.75% 是
HY-10331 Regorafenib Inhibitor 99.93% 是
HY-114370 Selpercatinib Inhibitor 99.83% 是
HY-10981A Lenvatinib mesylate Inhibitor 99.86% 是
HY-112301 Pralsetinib Inhibitor 99.98% 是
HY-10331A Regorafenib monohydrate Inhibitor 99.94% 是
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% 是
HY-10331B Regorafenib mesylate Inhibitor / 否
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2
HY-132846 Vepafestinib Inhibitor 98.61% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-100459 GSK3179106 Inhibitor 99.81% Phase 1
HY-139590 Zeteletinib Inhibitor 98.31% Phase 1
HY-149413 FHND5071 Inhibitor / Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99828 Cofetuzumab Inhibitor 99.31% Phase 1
Pre-clinical Phase
生物活性分子 (107)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15002 AST 487 Inhibitor 98.90% 否
HY-10410 TG101209 Inhibitor 98.81% 否
HY-124401 BT-13 Agonist 99.57% 否
HY-101963 AD80 Inhibitor 99.88% 否
HY-156135 NSC194598 Inhibitor 98.90% 否
HY-18840 BBT594 Inhibitor 99.86% 否
HY-U00437 Pz-1 Inhibitor 99.90% 否
HY-145565 Enbezotinib Inhibitor 99.50% 否
HY-153175 BT44 Activator 99.08% 否
HY-10981S Lenvatinib-d4 Inhibitor 99.59% 否
HY-101246 RPI-1 Inhibitor 99.29% 否
HY-136534 RET V804M-IN-1 Inhibitor 98.22% 否
HY-13342AS Apatinib-d8 free base 92.56% 否
HY-110193 SPP-86 Inhibitor 99.87% 否
HY-N10889 Sominone Activator 95.86% 否
HY-162565 CDD-2807 Inhibitor 99.52% 否
HY-112301A trans-Pralsetinib Inhibitor 96.07% 否
HY-133551 WF-47-JS03 Inhibitor 99.63% 否
HY-15769 WHI-P180 Inhibitor 99.84% 否
HY-18317 JNJ-38158471 Inhibitor 97.02% 否
HY-18507 AD57 Inhibitor 98.08% 否
HY-116116 Tafetinib Inhibitor 96.20% 否
HY-133553 RET-IN-3 Inhibitor 99.51% 否
HY-10331S Regorafenib-d3 Inhibitor ≥98.0% 否
HY-34595 Pyrazoloadenine Inhibitor 99.98% 否
HY-148742 RET-IN-21 Inhibitor 97.00% 否
HY-139590A Zeteletinib hemiadipate Inhibitor / 否
HY-132193 RET-IN-4 Inhibitor / 否
HY-145023 RET-IN-5 Inhibitor / 否
HY-146710 RET-IN-16 Inhibitor / 否
HY-159824 Soxataltinib Inhibitor / 否
HY-170854 RET Ligand-Linker Conjugate-1 Ligand / 否
HY-148015 Enbezotinib (enantiomer) Inhibitor 99.72% 否
HY-147563 RET-IN-17 Inhibitor / 否
HY-E70776 RET S891A Recombinant Human Active Protein Kinase / 否
HY-10331S1 Regorafenib-13C,d3 Inhibitor / 否
HY-151987 RET-IN-20 Inhibitor / 否
HY-170373 RET ligand-1 Inhibitor / 否
HY-E70769 RET G810R Recombinant Human Active Protein Kinase / 否
HY-144029 RET-IN-13 Inhibitor / 否
HY-170852 QZ2135 Degrader / 否
HY-E70772 RET L730M Recombinant Human Active Protein Kinase / 否
HY-170809 RET-IN-29 Inhibitor / 否
HY-E70777 RET V804E Recombinant Human Active Protein Kinase / 否
HY-141896 RET-IN-7 Inhibitor 98.00% 否
HY-E70779 RET V804M Recombinant Human Active Protein Kinase / 否
HY-149539 PLM-101 Inhibitor / 否
HY-143545 RET-IN-8 Inhibitor / 否
HY-174993 FHND5071 (1H) Inhibitor / 否
HY-170926 CQ1373 Inhibitor / 否
HY-E70774 RET R749T Recombinant Human Active Protein Kinase / 否
HY-143546 RET-IN-9 Inhibitor / 否
HY-151377 RET-IN-19 Inhibitor / 否
HY-153941 RET-IN-24 Inhibitor / 否
HY-170853 RET ligand-3 Degrader / 否
HY-144131 RET-IN-11 Inhibitor / 否
HY-E70778 RET V804L Recombinant Human Active Protein Kinase / 否
HY-143615 RET-IN-10 Inhibitor / 否
HY-120214 TAS05567 / 否
HY-117873 KBP-7018 Inhibitor / 否
HY-P10044 IGF1Rtide / 否
HY-E70770 RET G810S Recombinant Human Active Protein Kinase / 否
HY-156113 RET-IN-25 Inhibitor / 否
HY-10981S2 Lenvatinib-15N,d4 Inhibitor / 否
HY-E70768 RET G810C Recombinant Human Active Protein Kinase / 否
HY-E70766 RET E762Q Recombinant Human Active Protein Kinase / 否
HY-156471 RET-IN-26 Inhibitor / 否
HY-147564 RET-IN-18 Inhibitor / 否
HY-144170 RET-IN-14 Inhibitor / 否
HY-172952 LRRK2-IN-17 Inhibitor / 否
HY-149099 RET-IN-22 Inhibitor / 否
HY-114588 Tafetinib analogue 1 Inhibitor / 否
HY-18507A AD57 hydrochloride Inhibitor / 否
HY-14979 ML786 Inhibitor / 否
HY-14979A ML786 dihydrochloride Inhibitor / 否
HY-E70773 RET M918T Recombinant Human Active Protein Kinase / 否
HY-E70771 RET L730I Recombinant Human Active Protein Kinase / 否
HY-E70775 RET R813Q Recombinant Human Active Protein Kinase / 否
HY-161775 RET/TRKA-IN-1 Inhibitor / 否
HY-145024 RET-IN-6 Inhibitor / 否
HY-174245 RET-IN-30 Inhibitor / 否
HY-170019 RET-IN-28 Inhibitor / 否
HY-E70780 RET Y791F Recombinant Human Active Protein Kinase / 否
HY-10981S1 Lenvatinib-d5 Inhibitor / 否
HY-E70767 RET G691S Recombinant Human Active Protein Kinase / 否
HY-153676 RET-IN-23 Inhibitor / 否
HY-151945 TRK II-IN-1 Inhibitor / 否
HY-168105 RET-IN-27 Inhibitor / 否
HY-164413 CLM3 Inhibitor / 否
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / 否
HY-117873A KBP-7018 hydrochloride Inhibitor / 否
HY-168868 RET ligand-2 Inhibitor / 否
HY-149415 Multi-kinase-IN-5 Inhibitor / 否
HY-168867 RD-23 Inhibitor / 否
HY-146680 FLT3/ITD-IN-4 Inhibitor / 否
HY-144422 RET-IN-15 Inhibitor / 否
HY-170855A YW-N-7 TFA Degrader / 否
HY-E70781 RET Y806H Recombinant Human Active Protein Kinase / 否
HY-171146 HSN748 Inhibitor / 否
HY-18817 AFG210 Inhibitor / 否
HY-W759629 Selpercatinib-d3 Inhibitor / 否
HY-164482 HG-6-63-01 Inhibitor / 否
HY-164549 XMD15-44 Inhibitor / 否
HY-15769A WHI-P180 hydrochloride Inhibitor / 否
HY-149451 SYHA1815 Inhibitor / 否
HY-144030 RET-IN-12 Inhibitor / 否
HY-112950 RET-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens RET NCBI NCBI:5979
Macaca fascicularis RET NCBI NCBI:102135879
Mus musculus RET NCBI NCBI:19713
Susscrofa domestica RET NCBI
Rattus norvegicus RET NCBI NCBI:24716
Macaca mulatta RET NCBI NCBI:703466
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