2. Gene
  3. IL21R - interleukin 21 receptor Gene

IL21R - interleukin 21 receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 21 受体

种属: Homo sapiens

同用名: NILR; CD360; IMD56

基因 ID: 50615 | 基因类型: protein coding

关于 IL21R

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,402,174-27,452,042 (from NCBI)

This gene has 6 transcripts (splice variants), 131 orthologues, 7 paralogues and is associated with 70 phenotypes. Biased expression in lymph node (RPKM 10.1), appendix (RPKM 5.4) and 7 other tissues.

功能概要

该基因编码的蛋白质是白细胞介素 21 (IL21) 的细胞因子受体。它属于 I 型细胞因子受体，已被证明与共同的 γ 链形成异二聚体受体复合物，γ 链是白细胞介素 2、4、7、9 和 15 的受体也共享的受体亚基。该受体转导 IL21 的生长促进信号，对 T 细胞、B 细胞和自然杀伤 (NK) 细胞的增殖和分化很重要。该受体的配体结合导致多个下游信号分子的激活，包括 JAK1、JAK3、STAT1 和 STAT3。对小鼠中相似基因的敲除研究表明该基因在调节免疫球蛋白产生中的作用。已经描述了三种选择性剪接的转录本变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

IL21R 基因产物(3)

mRNA Protein Name
NM_021798.4 NP_068570.1 interleukin-21 receptor isoform 1 precursor
NM_181078.3 NP_851564.1 interleukin-21 receptor isoform 1 precursor
NM_181079.5 NP_851565.4 interleukin-21 receptor isoform 2 precursor
蛋白主名 其他名称

interleukin-21 receptor

IL-21 receptor

重组 IL21R 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72559 IL-21R Protein, Human (217a.a, HEK293, His) Q9HBE5 (C20-P236) ≥95%
HY-P73190 IL-21R Protein, Human (236a.a, HEK293, His) Q9HBE5 (M1-P236) ≥95%
HY-P73891 IL-21R Protein, Human (236a.a, HEK293, Fc) Q9HBE5 (M1-P236) ≥95%
HY-P77714 IL-21R Protein, Human (217a.a, HEK293, Fc) Q9HBE5 (C20-P236) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 56

Il21r Immunodeficiency

IMD56

Combined Immunodeficiency Due To Il21r Deficiency

Autosomal Recessive Primary Immunodeficiency Il21r-Related
Ige Responsiveness, Atopic

ATOPY

Atopy, Susceptibility To

Ige, Elevated Level Of

IGER

Immunoglobulin E, Basic Level Of, In Serum

Ige, Level Of

Igel

Ige Response Underlying Allergic Asthma And Rhinitis

Atopic Hypersensitivity

Immediate Hypersensitivity
Immunodeficiency 31c

IMD31C

Candidiasis, Familial, 7

Candf7

Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant

Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome

Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome

Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant

Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis

Autosomal Dominant Immunodeficiency 31c

Familial Candidiasis 7

Chronic Mucocutaneous Candidiasis 7

Immunodeficiency 31c, Autosomal Dominant

Immunodeficiency, Type 31c, Autosomal Dominant
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06735 IL21R Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IL21R VGNC VGNC:73727
Mus musculus IL21R MGD MGI:1890475
Rattus norvegicus IL21R RGD RGD:1304950
Felis catus IL21R VGNC VGNC:67775
Canis familiaris IL21R VGNC VGNC:41968
Bos taurus IL21R VGNC VGNC:30142
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