2. Gene
  3. STK26 - serine/threonine kinase 26 Gene

STK26 - serine/threonine kinase 26 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝氨酸/苏氨酸激酶 26

种属: Homo sapiens

同用名: MASK; MST4

基因 ID: 51765 | 基因类型: protein coding

关于 STK26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,023,302-132,075,943 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues.

功能概要

该基因的产物是 GCK III 类激酶家族的成员，是 Ste20 样激酶的一个子集。编码的蛋白质包含一个氨基末端激酶结构域和一个介导同源二聚化的羧基末端调节结构域。蛋白激酶定位于高尔基体，并通过与高尔基体基质蛋白 GM130 结合而被特异性激活。它也在体外被 Caspase-3 切割，并可能在细胞凋亡途径中发挥作用。已经描述了该基因的几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by Caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

STK26 基因产物(3)

mRNA Protein Name
NM_001042452.2 NP_001035917.1 serine/threonine-protein kinase 26 isoform 3
NM_001042453.2 NP_001035918.1 serine/threonine-protein kinase 26 isoform 2
NM_016542.4 NP_057626.2 serine/threonine-protein kinase 26 isoform 1

STK26 蛋白结构

Pkinase

Pkinase: Protein kinase domain (24 - 274)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase 26

Mst3 and SOK1-related kinase

重组 STK26 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74741 MST4/STK26 Protein, Human (sf9, GST) Q9P289-1 (M1-P416) ≥95%

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome

CCMS

Rib Gap Defects With Micrognathia

Ccm Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13929 STK26 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STK26 VGNC VGNC:81585
Mus musculus STK26 MGD MGI:1917665
Rattus norvegicus STK26 RGD RGD:1563568
Canis familiaris STK26 VGNC VGNC:46910
Felis catus STK26 VGNC VGNC:97648
Bos taurus STK26 VGNC VGNC:35392
Others STK26 NCBI
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