CDHR2 - cadherin related family member 2 Gene

中文名称：钙粘素相关家族成员 2

种属: Homo sapiens

同用名: PCLCK; PCLKC; PCDH24

基因 ID: 54825 | 基因类型: protein coding

关于 CDHR2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,542,511-176,595,974 (from NCBI)

This gene has 7 transcripts (splice variants), 116 orthologues and 33 paralogues. Biased expression in duodenum (RPKM 125.9), small intestine (RPKM 110.9) and 3 other tissues.

功能概要

该基因是原钙粘蛋白家族的成员，代表较大的钙粘蛋白超家族的一个子集。原钙粘蛋白家族的成员编码非经典钙粘蛋白，其作为钙依赖性细胞间粘附分子发挥作用。这种原钙粘蛋白代表了一种新的肿瘤抑制候选物。已经鉴定出编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2010 年 1 月]

This gene is a member of the protocadherin family, which represents a subset of the larger Cadherin superfamily. The members of the protocadherin family encode non-classical Cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]

CDHR2 基因产物(2)

mRNA	Protein	Name
NM_001171976.2	NP_001165447.1	cadherin-related family member 2 precursor
NM_017675.6	NP_060145.3	cadherin-related family member 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cell adhesion molecule binding	IDA IDA: 通过直接分析推断	24725409	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12117771	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in brush border assembly	IDA IDA: 通过直接分析推断	32209652	GOA
involved in cell-cell adhesion mediated by cadherin	IDA IDA: 通过直接分析推断	12117771	GOA
involved in epithelial cell differentiation	IDA IDA: 通过直接分析推断	12117771	GOA
involved in intermicrovillar adhesion	IMP IMP: 通过突变表型推断	24725409	GOA
involved in negative regulation of cell growth involved in contact inhibition	IDA IDA: 通过直接分析推断	12117771	GOA
involved in regulation of microvillus length	IMP IMP: 通过突变表型推断	24725409	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	12117771	GOA
located in brush border	IDA IDA: 通过直接分析推断	21330445	GOA
located in brush border membrane	IDA IDA: 通过直接分析推断	24725409	GOA
located in microvillus	IDA IDA: 通过直接分析推断	32209652	GOA
located in microvillus membrane	IDA IDA: 通过直接分析推断	12117771	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	24725409	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDHR2 蛋白结构

Cadherin

0
300
600
900
1200
1310 a.a.

蛋白主名

其他名称

cadherin-related family member 2

protocadherin-24

CDHR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDHR2	Q9BYE9	MYO7B	Homo sapiens	Q6PIF6	Anti Tag CoIP	24725409
种属内	CDHR2	Q9BYE9	MYO7B	Homo sapiens	Q6PIF6	Confocal	24725409
种属内	CDHR2	Q9BYE9	MAST2	Homo sapiens	Q6P0Q8	Y2H	12117771
种属内	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-1	Pull Down	24725409
种属内	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-1	SEM	24725409
种属内	CDHR2	Q9BYE9	USH1C	Homo sapiens	Q9Y6N9-1	Anti Tag CoIP	24725409
种属内	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	Pull Down	24725409
种属内	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	SEM	24725409
种属内	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	Bead Aggregation	24725409

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02344	CDHR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CDHR2	RGD	RGD:1560576
Bos taurus	CDHR2	VGNC	VGNC:27109
Canis familiaris	CDHR2	VGNC	VGNC:39038
Mus musculus	CDHR2	MGD	MGI:2687323
Felis catus	CDHR2	VGNC	VGNC:60689
Macaca mulatta	CDHR2	VGNC	VGNC:110476

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CDHR2 - cadherin related family member 2 Gene

关于 CDHR2

功能概要

CDHR2 基因产物(2)

CDHR2 蛋白结构

CDHR2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CDHR2 - cadherin related family member 2 Gene

关于 CDHR2

功能概要

CDHR2 基因产物(2)

CDHR2 蛋白结构

CDHR2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z