2. Gene
  3. MAST2 - microtubule associated serine/threonine kinase 2 Gene

MAST2 - microtubule associated serine/threonine kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管相关丝氨酸/苏氨酸激酶 2

种属: Homo sapiens

同用名: MTSSK; MAST205

基因 ID: 23139 | 基因类型: protein coding

关于 MAST2

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,803,612-46,036,122 (from NCBI)

This gene has 10 transcripts (splice variants), 227 orthologues and 13 paralogues. Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues.

功能概要

启用磷酸酶结合活性。预计参与多个过程，包括肽基丝氨酸磷酸化；调节白细胞介素 12 的产生；和精子细胞分化。预测位于细胞质和质膜。预计在微管细胞骨架中具有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables Phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MAST2 基因产物(4)

mRNA Protein Name
NM_001319245.2 NP_001306174.1 microtubule-associated serine/threonine-protein kinase 2 isoform 2
NM_001324320.2 NP_001311249.1 microtubule-associated serine/threonine-protein kinase 2 isoform 3
NM_001324321.2 NP_001311250.1 microtubule-associated serine/threonine-protein kinase 2 isoform 4
NM_015112.3 NP_055927.2 microtubule-associated serine/threonine-protein kinase 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
10646847 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12117771 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAST2 蛋白结构

DUF1908

DUF1908: Domain of unknown function (DUF1908) (201 - 476)

Pkinase

Pkinase: Protein kinase domain (512 - 785)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1134 - 1186)

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  • 1798 a.a.
蛋白主名 其他名称

microtubule-associated serine/threonine-protein kinase 2

microtubule associated testis specific serine/threonine protein kinase

MAST2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAST2 Q6P0Q8 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
MAST2 Q6P0Q8 CDHR2 Homo sapiens Q9BYE9
Imaging
12117771
种属内
MAST2 Q6P0Q8 CDHR2 Homo sapiens Q9BYE9
CoIP
12117771
种属内
MAST2 Q6P0Q8 SLC9A3 Homo sapiens P48764
Y2H
16159897
种属内
MAST2 Q6P0Q8 SLC9A3 Homo sapiens P48764
Pull Down
16159897
种属间
MAST2 Q6P0Q8 SLC9A3 Didelphis virginiana Q28362
Protein Kinase Assay
16159897
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM
Inflammatory Bowel Disease 6

IBD6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08162 MAST2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAST2 VGNC VGNC:31258
Mus musculus MAST2 MGD MGI:894676
Macaca mulatta MAST2 VGNC VGNC:74532
Canis familiaris MAST2 VGNC VGNC:43033
Rattus norvegicus MAST2 RGD RGD:1304573
Felis catus MAST2 VGNC VGNC:80276
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