1. Gene
  2. PSMA3 - proteasome 20S subunit alpha 3 Gene

PSMA3 - proteasome 20S subunit alpha 3 Gene

中文名称:蛋白酶体 20S 亚基 alpha 3

种属: Homo sapiens

同用名: HC8; PSC3

基因 ID: 5684 | 基因类型: protein coding

关于 PSMA3

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,244,843-58,272,004 (from NCBI)

This gene has 13 transcripts (splice variants), 245 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 46.2), lymph node (RPKM 44.1) and 25 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物,具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成; 2 个环由 7 个α亚基组成,2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中,并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码肽酶 T1A 家族的一个成员,即 20S 核心 alpha 亚基。已经确定了编码不同亚型的两个替代转录本。[RefSeq 提供,2008 年 7 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PSMA3 基因产物(2)

mRNA Protein Name
NM_002788.4 NP_002779.1 proteasome subunit alpha type-3 isoform 1
NM_152132.3 NP_687033.1 proteasome subunit alpha type-3 isoform 2

PSMA3 蛋白结构

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (8 - 30)

Proteasome

Proteasome: Proteasome subunit (31 - 217)

  • 0
  • 100
  • 200
  • 255 a.a.
蛋白主名 其他名称

proteasome subunit alpha type-3

macropain subunit C8

重组 PSMA3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75988 PSMA3 Protein, Human (His) P25788-1 (M1-M255) ≥95%

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Familial Cold Autoinflammatory Syndrome 4

FCAS4

Nlrc4-Related Familial Cold Autoinflammatory Syndrome

Nlrc4-Related Familial Cold Urticaria

Autoinflammatory, Cold, Familial, Syndrome, Type 4

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour

Atrophoderma Vermiculata

Atrophoderma Vermiculatum

Folliculitis Ulerythematosa Reticulata

Atrophodermia Vermiculata

Honeycomb Atrophy

Atrophodermia Reticulata Symmetrica Faciei

AVA

Atrophodermia Reticulata

Folliculitis Ulerythematosa

Folliculitis Ulerythematosa Reticulate

Burnett Schwartz Berberian Syndrome

Basal Ganglia Calcification

Fahr'S Syndrome

Fahr'S Disease

Fahr Disease

Basal Ganglia Disease

Basal Ganglia Diseases

Basal Ganglia Disorders

Abnormality Of The Basal Ganglia

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PSMA3 RGD RGD:61844
Mus musculus PSMA3 MGD MGI:104883
Canis familiaris PSMA3 VGNC VGNC:45090
Felis catus PSMA3 VGNC VGNC:69106
Bos taurus PSMA3 VGNC VGNC:33438
Others PSMA3 NCBI