2. Gene
  3. PSMA5 - proteasome 20S subunit alpha 5 Gene

PSMA5 - proteasome 20S subunit alpha 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酶体 20S 亚基 alpha 5

种属: Homo sapiens

同用名: PSC5; ZETA

基因 ID: 5686 | 基因类型: protein coding

关于 PSMA5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,399,042-109,426,448 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 14.6), appendix (RPKM 13.2) and 25 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物，具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成； 2 个环由 7 个α亚基组成，2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中，并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码肽酶 T1A 家族的一个成员，即 20S 核心 alpha 亚基。已为该基因发现编码两种不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PSMA5 基因产物(4)

mRNA Protein Name
NM_001199772.2 NP_001186701.1 proteasome subunit alpha type-5 isoform 2
NM_001199773.2 NP_001186702.1 proteasome subunit alpha type-5 isoform 2
NM_001199774.2 NP_001186703.1 proteasome subunit alpha type-5 isoform 2
NM_002790.4 NP_002781.2 proteasome subunit alpha type-5 isoform 1

PSMA5 蛋白结构

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (8 - 30)

Proteasome

Proteasome: Proteasome subunit (31 - 220)

  • 0
  • 100
  • 200
  • 241 a.a.
蛋白主名 其他名称

proteasome subunit alpha type-5

epididymis tissue sperm binding protein Li 11n

关联疾病

疾病名称 别名
Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11295 PSMA5 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PSMA5 RGD RGD:61848
Mus musculus PSMA5 MGD MGI:1347009
Canis familiaris PSMA5 VGNC VGNC:54060
Macaca mulatta PSMA5 VGNC VGNC:76440
Felis catus PSMA5 VGNC VGNC:80331
Bos taurus PSMA5 VGNC VGNC:33440
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z