Lmna - lamin A/C Gene

种属: Rattus norvegicus

关于 Lmna

功能概要

Enables protein Phosphatase 1 binding activity. Involved in several processes, including cellular senescence; negative regulation of adipose tissue development; and positive regulation of osteoblast differentiation. Located in nuclear matrix. Used to study transient cerebral ischemia. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Apr 2022]