2. Gene
  3. Pink1 - PTEN induced putative kinase 1 Gene

Pink1 - PTEN induced putative kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BRPK; mFLJ00387; 1190006F07Rik

基因 ID: 68943 | 基因类型: protein coding

关于 Pink1

功能概要

Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of dopamine secretion; positive regulation of dopaminergic synaptic transmission; and positive regulation of histone deacetylase activity. Located in endoplasmic reticulum and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Parkinson's disease 6. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pink1 基因产物(1)

mRNA Protein Name
NM_026880.2 NP_081156.2 serine/threonine-protein kinase PINK1, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
14607334 MGI
enables kinase activity IDA
IDA: 通过直接分析推断
14607334 MGI
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14607334 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
31536960 MGI
enables protein serine kinase activity IMP
IMP: 通过突变表型推断
32484300 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14607334 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
24784582 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of catecholamine secretion IMP
IMP: 通过突变表型推断
17563363 MGI
involved in cellular response to hypoxia IMP
IMP: 通过突变表型推断
24553947 MGI
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
18687901 MGI
involved in cellular response to toxic substance IMP
IMP: 通过突变表型推断
22511790 MGI
acts upstream of dopamine secretion IMP
IMP: 通过突变表型推断
17563363 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
17563363 MGI
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
14607334 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
24475098 MGI
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
24553947 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
18560593 MGI
acts upstream of or within positive regulation of catecholamine secretion IMP
IMP: 通过突变表型推断
17563363 MGI
acts upstream of or within positive regulation of dopamine secretion IMP
IMP: 通过突变表型推断
17563363 MGI
acts upstream of or within positive regulation of mitochondrial electron transport, NADH to ubiquinone IMP
IMP: 通过突变表型推断
24652937 MGI
acts upstream of or within positive regulation of synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
17563363 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24553947 MGI
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
24553947 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14607334 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
19229105 MGI
involved in regulation of hydrogen peroxide metabolic process IMP
IMP: 通过突变表型推断
24553947 MGI
involved in regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
22511790 MGI
involved in respiratory electron transport chain IMP
IMP: 通过突变表型推断
18687901 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
31536960 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
24652937 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
31536960 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase PINK1, mitochondrial

PTEN-induced putative kinase protein 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-152265A PARL-IN-1 TFA Activator / Phase 2
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100941 CCCP 99.83% 否
HY-100410 FCCP Activator 99.70% 否
HY-N0109 Salidroside 99.90% 否
HY-15887 MG 149 99.60% 否
HY-152943 MTK458 Activator 99.28% 否
HY-115576 P62-mediated mitophagy inducer 99.54% 否
HY-139308 T0467 99.30% 否
HY-145337 FT3967385 Inhibitor 99.74% 否
HY-122818 BpV(phen) trihydrate 98.0% 否
HY-136065 bpV(phen) 98.0% 否
HY-N0109R Salidroside (Standard) 99.82% 否
HY-163815 CDK2 degrader 2 Degrader 99.51% 否
HY-169380 PARL-IN-2 98.63% 否
HY-162325 WJ-39 99.60% 否
HY-RS10559 PINK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-125036 MitoBloCK-11 99.28% 否
HY-152265 PARL-IN-1 Activator / 否
HY-170343 PROTAC SMARCA2 degrader-32 Degrader / 否
HY-170390 AB3067 Degrader / 否
HY-170900 SJ44236 Degrader / 否
HY-170992 Autophagy agonist-1 / 否
HY-172359 PROTAC HDAC6 degrader 4 Degrader / 否
HY-174806 Y040-7904 / 否
HY-176485 Antiproliferative agent-70 Inducer / 否
HY-178154 FB231 / 否
HY-RS16608 Pink1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23042 Pink1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pink1 NCBI NCBI:65018
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