2. Gene
  3. Gsdmd - gasdermin D Gene

Gsdmd - gasdermin D Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik

基因 ID: 69146 | 基因类型: protein coding

关于 Gsdmd

功能概要

Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]

Gsdmd 基因产物(1)

mRNA Protein Name
NM_026960.4 NP_081236.1 gasdermin-D
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cardiolipin binding IDA
IDA: 通过直接分析推断
27383986 MGI
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
27383986 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
27383986 MGI
enables phosphatidylinositol-4-phosphate binding IDA
IDA: 通过直接分析推断
27383986 MGI
enables phosphatidylserine binding IDA
IDA: 通过直接分析推断
27383986 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
37327784 MGI
enables wide pore channel activity IDA
IDA: 通过直接分析推断
27339137 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to stimulus IDA
IDA: 通过直接分析推断
10322635 MGI
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
27383986 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
37988464 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
27383986 MGI
involved in pore complex assembly IDA
IDA: 通过直接分析推断
27383986 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
27383986 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
26611636 MGI
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
27383986 MGI
involved in protein secretion IDA
IDA: 通过直接分析推断
35705808 MGI
involved in pyroptotic cell death IDA
IDA: 通过直接分析推断
27339137 MGI
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
26611636 MGI
involved in pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
37988464 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLRP3 inflammasome complex IDA
IDA: 通过直接分析推断
26611636 MGI
located in cytosol IDA
IDA: 通过直接分析推断
27383986 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
27383986 MGI
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
37001519 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
27339137 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
27339137 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gasdermin-D

gasdermin domain containing 1

gasdermin domain-containing protein 1

gasderminD-1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0240 Disulfiram 99.77% 否
HY-B0240R Disulfiram (Standard) 99.54% 否
Pre-clinical Phase
生物活性分子 (25)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13453 BAY 11-7082 99.98% 否
HY-100381 Nigericin sodium salt 99.37% 否
HY-127019 Nigericin 99.43% 否
HY-100573 Necrosulfonamide 99.47% 否
HY-111674 LDC7559 Inhibitor 99.51% 否
HY-N0816 Polyphyllin VI 98.49% 否
HY-171006 IRF1-IN-1 Inhibitor 99.72% 否
HY-111675 Ac-FLTD-CMK Inhibitor 99.18% 否
HY-N2414 Periplogenin ≥99.70% 否
HY-W075517 ZIF-8 / 否
HY-152670 JC2-11 Inhibitor 98.03% 否
HY-171007 IRF1-IN-2 99.83% 否
HY-N0218 Benzoylmesaconine Inhibitor 99.56% 否
HY-RS05857 GSDMD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-100573A (E/Z)-Necrosulfonamide 98.84% 否
HY-156374 D359-0396 Inhibitor 99.98% 否
HY-161727 P2Y14R antagonist 1 98.58% 否
HY-100573S Necrosulfonamide-d4 99.26% 否
HY-130480 Fructose-arginine Inhibitor 98.32% 否
HY-RS16519 Gsdmd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-161332 Antitumor agent-143 / 否
HY-172788 NLRP3-IN-78 Inhibitor / 否
HY-173234 GI-Y2 Inhibitor / 否
HY-175640 Troponin-IN-1 Inhibitor / 否
HY-RS22950 Gsdmd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gsdmd NCBI NCBI:79792
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