ADAM9 - ADAM metallopeptidase domain 9 Gene

中文名称：ADAM 金属肽酶域 9

种属: Homo sapiens

同用名: MCMP; MDC9; CORD9; Mltng

基因 ID: 8754 | 基因类型: protein coding

关于 ADAM9

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,996,973-39,105,261 (from NCBI)

This gene has 28 transcripts (splice variants), 1 gene allele, 211 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues.

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。由该基因编码的蛋白质与包含 SH3 结构域的蛋白质相互作用，结合有丝分裂停滞缺陷的 2 β 蛋白质，并且还参与 TPA 诱导的膜锚定肝素结合 EGF 样生长因子的胞外域脱落。已经为该基因鉴定了几种选择性剪接的转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

ADAM9 基因产物(1)

mRNA	Protein	Name
NM_003816.3	NP_003807.1	disintegrin and metalloproteinase domain-containing protein 9 precursor

ADAM9 蛋白结构

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
819 a.a.

蛋白主名

其他名称

disintegrin and metalloproteinase domain-containing protein 9

ADAM metallopeptidase domain 9 (meltrin gamma)

重组 ADAM9 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77867	ADAM9 Protein, Human (HEK293, His)	Q13443 (A29-D697)	≥95%

关联疾病

疾病名称

别名

Cone-Rod Dystrophy 9

CORD9	Dystrophy, Cone-Rod, Type 9
Retinitis Pigmentosa 9

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Retinal Degeneration

Degeneration Of Retina

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P990027	Izeltabart		95.74%	Phase 2

Cat. No.	产品名	纯度	是否罕见病
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA	99.21%	否
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	/	否
HY-RS00289	ADAM9 Human Pre-designed siRNA Set A	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ADAM9	VGNC	VGNC:59585
Mus musculus	ADAM9	MGD	MGI:105376
Bos taurus	ADAM9	VGNC	VGNC:25613
Macaca mulatta	ADAM9	VGNC	VGNC:82097
Rattus norvegicus	ADAM9	RGD	RGD:621473
Canis familiaris	ADAM9	VGNC	VGNC:37588
Others	ADAM9	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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ADAM9 - ADAM metallopeptidase domain 9 Gene

关于 ADAM9

功能概要

ADAM9 基因产物(1)

ADAM9 蛋白结构

重组 ADAM9 蛋白

关联疾病

直系同源

热门区域

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ADAM9 - ADAM metallopeptidase domain 9 Gene

关于 ADAM9

功能概要

ADAM9 基因产物(1)

ADAM9 蛋白结构

重组 ADAM9 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z