1. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  2. ADC Antibody MMP
  3. Izeltabart

Izeltabart  (Synonyms: IMGC-936 antibody; MGA021)

目录号: HY-P990027 纯度: 98.03%
COA 技术支持

Izeltabart (MGA021) 是一种靶向 ADAM9 的人源化 IgG1 单克隆抗体。Izeltabart 可作为 ADC Antibody 合成 ADC 分子 IMGC936 (Izeltabart Tapatansine)。Izeltabart 可用于肿瘤的研究。

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CAS No. : 2642078-60-0

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规格 价格 是否有货 数量
1 mg ¥3000
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Izeltabart (MGA021) is a humanized IgG1 monoclonal antibody targeting ADAM9, which can be used as an ADC Antibody to synthesize the ADC molecule IMGC936 (Izeltabart Tapatansine). Izeltabart can be used in the study of cancer[1].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Human

IC50 & Target

ADAM9

体外研究
(In Vitro)

ADC 分子 IMGC936 是由高亲和力人源化抗体 Izeltabart 和 DM21 (HY-139441) 偶联而成,IMGC936 具有抗肿瘤的活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
基因 ID

8754  [NCBI]

Accession

Q13443-1

分子量

147.4 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized ADAM9 Protein, Human (HEK293, His, HY-P77867A) can bind Izeltabart. The EC50 for this effect is 11.35 ng/mL.
纯度 & 产品资料

纯度: 98.03%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Izeltabart
目录号:
HY-P990027
需求量: