BMF - Bcl2 modifying factor Gene

中文名称：Bcl2 修饰因子

种属: Homo sapiens

关于 BMF

功能概要

该基因编码的蛋白质属于 BCL2 蛋白家族。 BCL2 家族成员形成异二聚体或同二聚体，并作为参与多种细胞活动的抗或促凋亡调节剂。该蛋白包含一个 BCL2 同源结构域 3 (BH3) ，并已显示可结合 BCL2 蛋白并作为凋亡激活剂发挥作用。发现这种蛋白质通过与动力蛋白轻链 2 的结合而与肌球蛋白 V 马达隔离，这可能对感知细胞内损伤和触发细胞凋亡很重要。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to Myosin V motors by its association with dynein LIGHT chain 2, which may be important for sensing intracellular damage and triggering Apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]