GLP-1(32-36)amide 

GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice^[1][2].

GLP-1 (32-36) amide (0.1-10 μM；24 小时) 可保持细胞活力，并降低 INS-1 细胞中 Streptozotocin (HY-13753) (STZ；1 μM) 诱导的细胞凋亡^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GLP-1 (32-36) amide (1 μMol/kg；腹腔注射；once daily for 21 d) 保护胰岛免受损伤，抑制体重增加，减轻糖尿病小鼠的烦渴症状^[2]。
GLP-1 (32-36) amide (1 μMol/kg；单次腹腔注射) 在正常小鼠葡萄糖攻击后 30 分钟略微降低平均葡萄糖水平^[2]。
GLP-1 (32-36) amide (50-70 nmol/kg/d；输注 12-16 周) 可防止高脂喂养小鼠出现饮食诱导的肥胖和肝脂肪变性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

570.73

C₂₅H₅₀N₁₀O₅

1417302-71-6

固体

White to off-white

Leu-Val-Lys-Gly-Arg-NH2

LVKGR-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Elahi D, et, al. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4.  [Content Brief]

  [2]. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86(6):1482-90.  [Content Brief]

  [3]. Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19.  [Content Brief]