2. Membrane Transporter/Ion Channel Antibody-drug Conjugate/ADC Related Apoptosis
  3. GLUT ADC Cytotoxin Apoptosis
  4. Glucopiericidin A

Glucopiericidin A 是一种天然的哌啶菌素化合物，可在海洋衍生的链霉菌菌株发现。Glucopiericidin A 充当葡萄糖转运蛋白 (GLUT) 的化学探针，可以抑制糖酵解。Glucopiericidin A 与 Piericidin A (PA; HY-114936) 协同可以抑制 ATP 依赖性丝状伪足突起，而单独使用没有作用。Glucopiericidin A 通过增加 PRDX1 降低活性氧 (ROS) 水平来诱导细胞凋亡，同时在 ACHN 小鼠异种移植物中也表现出有效的抗肿瘤功效。

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Glucopiericidin A Chemical Structure

Glucopiericidin A Chemical Structure

CAS No. : 108073-65-0

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Glucopiericidin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].

体外研究
(In Vitro)

Glucopiericidin A has cytotoxicities against three renal carcinoma cell lines, ACHN (IC50=0.21 μM), OS-RC-2 (IC50>100 μM), and 786-O (IC50>100 μM), as well as a normal renal cell line, HK-2 (IC50>100 μM)[2].
Glucopiericidin A (25, 50 nM; 24 h) causes the upregulation of PRDX1 in ACHN cells[2].
Glucopiericidin A (25, 50 nM; 24 h) not only raises the expression of mRNA and protein of PRDX1 but also forces it into the nucleus[2].
Glucopiericidin A (25, 50 nM; 24 h) reduces ROS in normal ACHN cells[2].
Neither Glucopiericidin A (GPA) nor Piericidin A (PA) alone, at concentrations up to 500 nM and 2.3 mM, respectively, shows inhibitory activity. When combined, much lower concentrations of GPA (17 nM) and PA (0.68 nM) produces inhibition of filopodia protrusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glucopiericidin A 相关抗体:

Western Blot Analysis[2]

Cell Line: ACHN cells
Concentration: 25 and 50 nM
Incubation Time: 24 hours
Result: Caused the upregulation of PRDX1 in ACHN cells.

RT-PCR[2]

Cell Line: ACHN cells
Concentration: 25 and 50 nM
Incubation Time: 24 hours
Result: Not only raised the expression of mRNA and protein of PRDX1 but also forced it into the nucleus
体内研究
(In Vivo)

Glucopiericidin A (0.8 mg/kg/day; IP; for three weeks) significantly reduces the final tumor weight of the mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing ACHN tumor xenografts[2]
Dosage: 0.8 mg/kg
Administration: IP; daily; for three weeks
Result: Significantly reduced the final tumor weight of the mice.
Increased the mRNA and protein expression of PRDX1 in tumor tissues.
分子量

577.71

Formula

C31H47NO9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glucopiericidin A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucopiericidin A108073-65-0GLUTADC CytotoxinApoptosisGlucose transporter ADC PayloadglucosetransporterglycolysisfilopodiaprotrusionPiericidin AreactiveoxygenspeciesPRDX1ACHNOS-RC-2786-OHK-2Inhibitorinhibitorinhibit

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