2. Apoptosis
  3. Apoptosis
  4. (Gly14)-Humanin (human)

(Gly14)-Humanin (human)  (Synonyms: 14-Glycine-Humanin (human))

目录号: HY-P3993
产品使用指南

摩尔计算器

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) 是 Humanin 的类似物，其中第 14 个氨基酸丝氨酸被甘氨酸 (Gly) 取代。(Gly14)-Humanin (human) 具有抗细胞凋亡和神经保护功能。

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Custom Peptide Synthesis

(Gly14)-Humanin (human) Chemical Structure

(Gly14)-Humanin (human) Chemical Structure

CAS No. : 330936-70-4

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(Gly14)-Humanin (human) 的其他形式现货产品:

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(Gly14)-Humanin (human) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions[1][2].

体外研究
(In Vitro)

(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值 。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Gly14)-Humanin (human) 相关抗体:

Cell Viability Assay[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 100 nM, 1 μM and 10 μM
Incubation Time: Pretreatment 3 hours and then treated with 72 hours
Result: Significantly increased cell viability.

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM
Incubation Time: Pretreatment 3 hours and then treated with 72 hours
Result: Reduced the ratio of bax/bcl-2.
体内研究
(In Vivo)

(Gly14)-Humanin (human)（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2]
Dosage: 0.1 μg/5 μL
Administration: Intracerebroventricularly (i.c.v.); once
Result: Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.
分子量

2657.21

Formula

C118H202N34O31S2
CAS 号
Sequence Shortening

MAPRGFSCLLLLTGEIDLPVKRRA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Gly14)-Humanin (human) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Gly14)-Humanin (human)330936-70-414-Glycine-Humanin (human)Apoptosisbaxbcl-2PARPROSanti-apoptoticneuroprotectiveInhibitorinhibitorinhibit

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