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GNE-0439 

目录号: HY-123824
产品使用指南

GNE-0439 是一种新型 Nav1.7 选择性抑制剂,IC50 为 0.34 uM,抑制 Nav1.5,IC50 为 38.3 μM。GNE-0439 在膜电位测定中抑制突变体 N1742K 通道(IC50=0.37 uM)。GNE-0439 具有羧酸基团,结合在通道孔外,与已知的选择性 VSD4 结合剂不同。

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GNE-0439 Chemical Structure

GNE-0439 Chemical Structure

CAS No. : 1241902-40-8

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Description

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1].

IC50 & Target

IC50: 0.34 uM (Nav1.7)[1]

Molecular Weight

345.48

Formula

C₂₁H₃₁NO₃

CAS No.

1241902-40-8

SMILES

CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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× = ×
C1   V1   C2   V2

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产品名称:
GNE-0439
目录号:
HY-123824
需求量:

GNE-0439

Cat. No.: HY-123824