2. Apoptosis Immunology/Inflammation
  3. TNF Receptor Apoptosis Interleukin Related Caspase
  4. Golimumab

Golimumab  (Synonyms: CNTO-148)

目录号: HY-P99111 纯度: 99.68%
COA

摩尔计算器

Golimumab (CNTO-148) 是一种有效的人 IgG1 TNFα 拮抗剂单克隆抗体。Golimumab 具有抗炎活性，并抑制 IL-6 和 IL-1β 的产生。Golimumab 通过靶向和中和 TNF 来防止炎症发生和软骨或骨骼的破坏。Golimumab 具有抗癌活性并诱导细胞凋亡 (apoptosis)。Golimumab 可用于类风湿关节炎、克罗恩病和癌症研究。

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Golimumab Chemical Structure

Golimumab Chemical Structure

CAS No. : 476181-74-5

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规格 价格 是否有货 数量
1 mg ￥3700
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5 mg ￥8500
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Golimumab 相关抗体

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research[1][2][3].

IC50 & Target[1]

IL-1

 

IL-6

 

CD40

 

体外研究
(In Vitro)

Golimumab (CNTO-148) (0.1-10 μg /mL; 24-72 hours; transmembrane TNFα–transfected Jurkat cells) induces reductions in the viability of transmembrane TNFα–expressing cells[1].
Golimumab (CNTO-148) (10 μg /mL; 48 hours; transmembrane TNFα–transfected Jurkat cells) induces apoptosis, increase the levels of active caspase-3 and induces apoptotic DNA fragmentation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Golimumab 相关抗体:

Cell Viability Assay[1]

Cell Line: Transmembrane TNFα–transfected Jurkat cells
Concentration: 0.1, 1 and 10 μg/mL
Incubation Time: 24, 48 and 72 hours
Result: Reduced cell viability in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: Transmembrane TNFα–transfected Jurkat cells
Concentration: 10 μg /mL
Incubation Time: 48 hours
Result: Had the percentage of apoptotic cells for 30.29%.

Western Blot Analysis[1]

Cell Line: Transmembrane TNFα–transfected Jurkat cells
Concentration: 10 μg /mL
Incubation Time: 48 hours
Result: Increased the levels of active caspase-3 and induces apoptotic DNA fragmentation.
体内研究
(In Vivo)

Golimumab (CNTO-148) (24 mg/kg; i.h.; daily, for 7 days; swiss-albino healthy male mice) inhibits oxidative stress, apoptotic cell death inflammatory response, thus improving renal function. Golimumab reduces all markers of kidney injury and attenuates cell death[2].
Golimumab (CNTO-148) (1-10 mg/kg; i.p.;daily; for 4 weeks; Tg197 transgenic mouse model) relieves TNFα-induced arthritis in a mouse model of human[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss-albino healthy male mice[2]
Dosage: 24 mg/kg
Administration: Subcutaneous injection; daily, for 7 days
Result: Reduced serum parameters like BUN, NGAL creatinine, cystatin C, and urinary parameters like KIM-1, NAG, albumin clusterin.
Animal Model: Swiss-albino healthy male mice[2]
Dosage: 24 mg/kg
Administration: Subcutaneous injection; daily, for 7 days
Result: Inhibited oxidative stress, reduces MDA concentrations and increases the GSH and catalase levels.
Animal Model: Swiss-albino healthy male mice[2]
Dosage: 24 mg/kg
Administration: Subcutaneous injection; daily, for 7 days
Result: Inhibitd cisplatin-induced inflammation, decreased TNF-α, including IL-6, IL-1β, MCP-1, ICAM-1, and TGF-β1 levels and increases IL-10 concentrations, reduced caspase 3 in cisplatin injected mice kidneys.
Animal Model: Tg197 transgenic mouse model[3]
Dosage: 1 and 10 mg/kg
Administration: Intraperitoneal injection;for 4 weeks
Result: Reduced the arthritic index.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.68%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Golimumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Golimumab476181-74-5CNTO-148CNTO148CNTO 148TNF ReceptorApoptosisInterleukin RelatedCaspaseTumor Necrosis Factor ReceptorTNFRILapoptosisTNFαanticanceranti- inflammation cytokinesInhibitorinhibitorinhibit

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