2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. Gymnestrogenin

Gymnestrogenin  (Synonyms: 匙羹藤苷元)

目录号: HY-N2273 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Gymnestrogenin 是来自 Gymnema sylvestre R.Br. 叶片的五羟基三萜。Gymnestrogenin 是一种有效的 LXR 拮抗剂，对 LXRα 和 LXRβ 反式激活的 IC50 分别为 2.5 和 1.4 μM。Gymnestrogenin 在其自身的启动子上也会降低 LXR 的转录活性，从而降低 mRNA 的表达。

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Gymnestrogenin Chemical Structure

Gymnestrogenin Chemical Structure

CAS No. : 19942-02-0

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规格 价格 是否有货 数量
1 mg ￥1600
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5 mg ￥4080
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Gymnestrogenin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2].

IC50 & Target

IC50: 2.5 μM (LXRα) and 1.4 μM (LXRβ)[2]
体外研究
(In Vitro)

Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gymnestrogenin 相关抗体:
分子量

490.72

Formula

C30H50O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

匙羹藤苷元
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

COA (195 KB)

产品使用指南 (1538 KB)
参考文献

Gymnestrogenin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gymnestrogenin19942-02-0匙羹藤苷元LXRLiver X receptorLXRαLXRβtranscriptionalactivityInhibitorinhibitorinhibit

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