1. GPCR/G Protein
  2. Leukotriene Receptor
  3. HAMI 3379

HAMI 3379 是一种有效的选择性 CysLT2 受体拮抗剂。HAMI 3379 对急性和亚急性缺血性脑损伤具有保护作用,并减轻小胶质细胞相关炎症。

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HAMI 3379 Chemical Structure

HAMI 3379 Chemical Structure

CAS No. : 1245653-57-9

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10 mg ¥3700
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25 mg ¥7400
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查看 Leukotriene Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HAMI 3379 is a potent and selective CysLT2 receptor antagonist. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury, and attenuates microglia-related inflammation[1][2].

IC50 & Target[1]

CysLT2

 

体外研究
(In Vitro)

In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes leukotriene D4- (LTD4-) and leukotriene C4- (LTC4-) induced intracellular calcium mobilization with IC50 values of 3.8 nM and 4.4 nM respectively. HAMI3379 exhibits very low potency on a recombinant CysLT1 receptor cell line (IC50>10000 nM). HAMI3379 does not exhibit any agonistic activity on both CysLT receptor cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

HAMI 3379 (0.025-0.4 mg/kg; ip) with 0.1-0.4 mg/kg significantly reduces the infarct volume and percentage increase in the ischemic/contralateral hemispheric ratio[2].
HAMI3379 (0.1 mg/kg; ip) administered at 0 and 1 h after reperfusion reduces infarct volume, attenuated brain edema, reduced neurological score, and increased holdingangle[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g) after MCAO[2]
Dosage: 0.025, 0.05, 0.1, 0.2, 0.4 mg/kg
Administration: IP
Result: Significantly reduced the infarct volume and percentage increase inthe ischemic/contralateral hemispheric ratio (an index ofbrain edema) with 0.1-0.4 mg/kg.
Significantly reduced the neurological deficit score.
分子量

595.72

Formula

C34H45NO8

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (167.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6786 mL 8.3932 mL 16.7864 mL
5 mM 0.3357 mL 1.6786 mL 3.3573 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.76%

参考文献

HAMI 3379 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6786 mL 8.3932 mL 16.7864 mL 41.9660 mL
5 mM 0.3357 mL 1.6786 mL 3.3573 mL 8.3932 mL
10 mM 0.1679 mL 0.8393 mL 1.6786 mL 4.1966 mL
15 mM 0.1119 mL 0.5595 mL 1.1191 mL 2.7977 mL
20 mM 0.0839 mL 0.4197 mL 0.8393 mL 2.0983 mL
25 mM 0.0671 mL 0.3357 mL 0.6715 mL 1.6786 mL
30 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3989 mL
40 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL
50 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
60 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
80 mM 0.0210 mL 0.1049 mL 0.2098 mL 0.5246 mL
100 mM 0.0168 mL 0.0839 mL 0.1679 mL 0.4197 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
HAMI 3379
目录号:
HY-112248A
需求量: