2. Epigenetics
  3. WDR5 Histone Methyltransferase
  4. HBI-2375

HBI-2375 (HYBI-084) 是一种选择性、可渗透血脑屏障的、口服有效的 MLL1-WDR5 相互作用抑制剂。HBI-2375 抑制 WDR5 的 IC50 为 4.48 nM。HBI-2375 在 MV4;11 白血病细胞中显示出增殖抑制 (IC50：3.17 µM)。HBI-2375 能够靶向破坏癌细胞中的组蛋白甲基转移酶 (histone methyltransferase) 活性。HBI-2375 可用于研究白血病、胶质瘤和胶质母细胞瘤。

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HBI-2375

HBI-2375 Chemical Structure

CAS No. : 2982574-79-6

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HBI-2375 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBI-2375 (HYBI-084) is a selective, brain-penetrant and orally active MLL1-WDR5 interaction inhibitor. HBI-2375 inhibits WDR5 with an IC50 of 4.48 nM. HBI-2375 shows inhibition of proliferation in MV4;11 leukemia cells (IC50: 3.17 µM). HBI-2375 is capable of targeted disruption of histone methyltransferase activity in cancer cells. HBI-2375 can be used for the study of leukemia, glioma and glioblastoma[1][2].

分子量

616.11

Formula

C29H36ClF2N9O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HBI-2375 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBI-23752982574-79-6HYBI-084HBI2375HBI 2375HYBI084HYBI 084WDR5Histone MethyltransferaseWD repeat protein-5WD40 repeat domain protein 5brain-penetrantorally activeMLL1-WDR5 interaction inhibitorleukemiaglioma and glioblastomaH3K4meInhibitorinhibitorinhibit

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目录号：
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