2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-71

HDAC-IN-71 (Compound 17q) 是一种有效的 HDAC 抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC10 的 IC50 值分别为 12.6、14.1、20、3、72 nM。HDAC-IN-71 可诱导细胞凋亡 (Apoptosis)，用于癌症的研究。

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HDAC-IN-71 Chemical Structure

HDAC-IN-71 Chemical Structure

CAS No. : 2995354-52-2

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HDAC-IN-71 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC50 values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research[1].

IC50 & Target

HDAC1

12.6 nM (IC50)

HDAC2

14.1 nM (IC50)

HDAC3

20 nM (IC50)

HDAC6

3 nM (IC50)

HDAC10

72 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-71 (0-1.6 μM; 24 h) 以剂量依赖性方式抑制菌落的形成，并且在 3.2 μM 浓度完全抑制 DU145 细胞的菌落形成[1]。
HDAC-IN-71 (0-1.6 μM; 72 h) 将细胞阻滞在 G2/M 期，并以浓度依赖性方式诱导 DU145 细胞系凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-71 相关抗体:

Cell Migration Assay [1]

Cell Line: DU145 cells
Concentration: 0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time: 12 h
Result: Inhibited cancer cell migration.

Cell Cycle Analysis[1]

Cell Line: DU145 cells
Concentration: 0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time: 72 h
Result: Arrested cells in G2/M phase in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: DU145 cells
Concentration: 0.8, 1.6, 3.2 μM
Incubation Time: 24 h
Result: Induced histone acetylation and inhibited HDAC6 expression.
体内研究
(In Vivo)

HDAC-IN-71 (100, 200 mg/kg; p.o.; daily; 40 days) 在100 mg/kg 和 200 mg/kg 浓度下肿瘤生长抑制（TGI）值分别为 50.92% 和 68.00%[1]。
药代动力学分析[1]

Parameters I.V. (2 mg/kg) P.O. (10 mg/kg)
AUC0-∞ (h ng/mL) 1633.35 3799.46
T1/2 (h) 3.12 2.87
CL (L/h/kg) 1.57
V (L/kg) 4.63
Cmax(ng/mL) 851.5 774.0
F 46.52%

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice[1]
Dosage: 100, 200 mg/kg
Administration: Oral administration; daily; 40 days
Result: Significantly inhibited prostate cancer (PCa) tumor growth.
分子量

360.40

Formula

C19H24N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-71 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-712995354-52-2HDACApoptosisHistone deacetylasesProstate cancerItaconimideAntiproliferativeInhibitorinhibitorinhibit

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目录号：
HY-163430
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