2. Peptides
  3. Helospectin II

Helospectin II 是血管活性肠肽 (VIP) 家族的神经肽。Helospectin II 具有血管扩张和抗高血压活性，并可降低血压。Helospectin II 最初是从蜥蜴 Heloderma suspectum 的唾液腺毒液中分离出来的。

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Helospectin II Chemical Structure

Helospectin II Chemical Structure

CAS No. : 93585-83-2

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Helospectin II 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum[1][2].

IC50 & Target

Vasoactive intestinal peptide (VIP) receptor[1]
体外研究
(In Vitro)

Helospectin II (suffusion at 0.1 nM, in bicarbonate buffer for 30 min) evokes significant, sustained and similar vasodilation in the intact hamster cheek pouch[1].
Helospectin II relaxes the Phenylephrine-contracted rat femoral arteries with pEC50 of 6.93[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Helospectin II 相关抗体:
体内研究
(In Vivo)

Helospectin II (0.03-2 nmol/kg, 100 μL of infusion at the left jugular vein) reduces blood pressure in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[2]
Dosage: 0.03, 0.3, 1, 2 nmol/kg
Administration: 100 μL of infusion at the left jugular vein, followed by washing the catheter with 100 μL saline.
Result: Reduced the blood pressure, but was less effective than vasoactive intestinal peptide (VIP) in the low dose range.
分子量

4008.55

Formula

C180H288N46O57
CAS 号
Sequence

His-Ser-Asp-Ala-Thr-Phe-Thr-Ala-Glu-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-Ser-Pro-Arg-Pro-Pro-Ser
Sequence Shortening

HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Helospectin II93585-83-2OthersVasodilatoryantihypertensiveblood pressureneuropeptidehamsterfemoral arteriesInhibitorinhibitorinhibit

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目录号：
HY-P3050
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