1. NF-κB
  2. NF-κB
  3. IKKγ NBD Inhibitory Peptide TFA

IKKγ NBD Inhibitory Peptide TFA 

目录号: HY-P1847A 纯度: 99.31%
COA 产品使用指南

IKKγ NBD 抑制肽 TFA 是一种高度特异性的 NF-κB 抑制剂。IKKγ NBD 抑制肽 TFA 通过阻断 IKKγ/NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用,而阻断 TNF-α 诱导的 NF-κB 激活。IKKγ NBD 抑制肽 TFA 可显著降低炎症、改善脑缺血所致的神经功能缺损。

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Custom Peptide Synthesis

IKKγ NBD Inhibitory Peptide TFA Chemical Structure

IKKγ NBD Inhibitory Peptide TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥1363
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5 mg ¥3000
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10 mg ¥4800
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查看 NF-κB 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor NF-κB inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits[1][2][3].

体外研究
(In Vitro)

在一个典型途径中,NF-κB 的激活依赖于 IKK 复合体的活性,该复合体由三个亚基 (IKKκ、IKKβ 和 IKKγ/NEMO) 组成,因此,KKγ NBD 抑制肽TFA 抑制 TNF-α 诱导的 NF- kb激活[2]
IKKγ NBD 抑制肽 TFA (10 μM; 90 min) 能够阻碍 Doxorubicin (HY-15142A) 诱导 (15 μM;4 h) 的 BT-474 细胞中 p65 磷酸化[2]
IKKγ NBD 抑制肽 TFA (10 μM; 48 h) 对BT-474细胞活力有轻微抑制作用,而对 Doxorubicin 的效力有增强作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

IKKγ NBD 抑制肽TFA (40 μg/4 μL;ICV; 单剂量; 于 MCAO 诱导前 2 h) 在大鼠模型脑中动脉闭塞 (MCAO) 模型中显示出神经保护作用,减少 DNA 碎片化,其机制可能与减少缺血损伤后的炎症有关[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (255 g) with middle cerebral artery occlusion (MCAO)[3]
Dosage: 40 μg/4 μL
Administration: Intracerebroventricular injection; 2 h before MCAO induction
Result: Significantly reduced striatal IL-1b level in IKK-NBD peptide treated rats.
Also resulted in reduced staining of microglial OX-42 and protection of BBB from ischemic insult.
分子量

3807.32

Formula

C172H260N49F3O44S1

性状

固体

颜色

White to off-white

Sequence Shortening

DRQIKIWFQNRRMKWKKTALDWSWLQTE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料

纯度: 99.31%

参考文献

IKKγ NBD Inhibitory Peptide TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
IKKγ NBD Inhibitory Peptide TFA
目录号:
HY-P1847A
需求量: