2. Inhibitory Antibodies
  3. IMAB027

IMAB027  (Synonyms: ASP1650)

目录号: HY-P99413 纯度: 95.00%
COA

摩尔计算器

IMAB027 (ASP1650) 是一种特异性抗 CLDN6 单克隆抗体，而 CLDN6 (Claudin 6) 是一种紧密连接膜蛋白，在各种人类癌症类型中异常表达，尤其是在卵巢癌中。IMAB 027 具有抗肿瘤活性，并诱导 CLDN6+ 卵巢癌和睾丸癌细胞凋亡。

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IMAB027 Chemical Structure

IMAB027 Chemical Structure

CAS No. : 1650599-68-0

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规格 价格 是否有货 数量
1 mg ￥3200
In-stock
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Customer Review

IMAB027 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines[1].

IC50 & Target

CLDN6[1]
体外研究
(In Vitro)

IMAB027 特异性地与 CLDN6 结合，而不是与其他密切相关的家族成员，如 Claudins 3，4 和 9 结合[1]。
IMAB027 在表达 CLDN6+ 的卵巢癌和睾丸癌细胞系中诱导靶细胞产生选择性抗体依赖细胞介导的细胞毒性 (ADCC) 和补体依赖细胞毒性 (CDC)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IMAB027 相关抗体:
体内研究
(In Vivo)

IMAB027 可降低人 CLDN6+ 细胞移植的小鼠肿瘤的肿瘤生长并提高总生存率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMAB0271650599-68-0ASP1650IMAB 027IMAB-027ASP 1650ASP-1650OthersInhibitorinhibitorinhibit

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