1. Immunology/Inflammation
  2. Macrophage migration inhibitory factor (MIF)
  3. Imalumab

Imalumab  (Synonyms: 伊玛鲁单抗; BAX69; Anti-Human MIF Recombinant Antibody)

目录号: HY-P99262 纯度: 98.37%
COA 技术支持

Imalumab (BAX69) 是重组的,人 IgG1 单克隆抗体,靶向巨噬细胞抑制因子 (MIF)。Imalumab 可用于卵巢癌、复发性恶性腹水和恶性肿瘤的研究。

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CAS No. : 1430205-07-4

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规格 价格 是否有货 数量
1 mg ¥3400
In-stock
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10 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer[1].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Human

IC50 & Target

MIF

体外研究
(In Vitro)

Imalumab 特异性结合氧化巨噬细胞移动抑制因子 (oxMIF),干扰下游信号通路。Imalumab 可诱导抗体依赖性细胞毒性 (ADCC) 和抗体依赖性细胞吞噬作用 (ADCP),并诱导人外周血单个核细胞 (PBMC) 细胞裂解,EC50 为 0.7-39.2 nM[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Imalumab (5 mg/kg, iv) 在 BALB/c 小鼠模型中的终末半衰期为 37.4 小时[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
基因 ID

4282  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

144.52 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

伊玛鲁单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: 98.37%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Imalumab
目录号:
HY-P99262
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