2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR
  3. EGFR ERK Akt
  4. Isoprocurcumenol

Isoprocurcumenol 是一种愈创木醚型倍半萜烯，可从 Curcuma comosa 中分离得到。Isoprocurcumenol 可以激活 EGFR 信号。Isoprocurcumenol 增加 ERK 和 AKT 的磷酸化。Isoprocurcumenol 可促进角质形成细胞的增殖。

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Isoprocurcumenol Chemical Structure

Isoprocurcumenol Chemical Structure

CAS No. : 102130-90-5

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Isoprocurcumenol 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].

IC50 & Target

ERK

 

Akt

 

体外研究
(In Vitro)

Isoprocurcumenol (10 μM, 0-1 h) 可促进 ERK 和 AKT 的磷酸化[3]。
Isoprocurcumenol (0-200 μM, 24 or 48 h) 诱导角质形成细胞 HaCaT 细胞增殖[3]。
Isoprocurcumenol (1 μM, 1 h) 通过激活 EGFR 信号通路增加细胞生长和增殖相关基因的表达，例如 c-fos、c-jun、c-myc 和 egr-1[ 3]。
Isoprocurcumenol 诱导细胞恢复和伤口愈合[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isoprocurcumenol 相关抗体:

Western Blot Analysis[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 10 μM
Incubation Time: 10, 30, or 60 min
Result: Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h.

Cell Proliferation Assay[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM
Incubation Time: 24 or 48 h
Result: Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM.

RT-PCR[3]

Cell Line: HaCaT cells (human keratinocyte cell)
Concentration: 1 μM
Incubation Time: 1 h
Result: Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.
分子量

234.33

Formula

C15H22O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isoprocurcumenol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Isoprocurcumenol102130-90-5EGFRERKAktEpidermal growth factor receptorErbB-1HER1Extracellular signal regulated kinasesPKBProtein kinase BKeratinocytewound healingCurcuma comosaHaCaT cellsCurcuma zedoariaInhibitorinhibitorinhibit

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